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ERCC1-XPF-IN-2

Name: ERCC1-XPF-IN-2
Brand: TargetMol
SKU: T60904
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60904Cas No. 1808986-37-9

ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].

ERCC1-XPF-IN-2

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Purity: 98.21%

Catalog No. T60904Cas No. 1808986-37-9

ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$497	In Stock	In Stock
200 mg	$693	-	In Stock
500 mg	$1,080	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.21%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].

In vitro

ERCC1-XPF-IN-2 (compound 13) (0-100 µM) exhibits DNase I and FEN-1 activity with IC50s of >100 µM, and shows binding kinetics with a Kd of ~30 µM. It is non-toxic to Hep-G2 cells at 10 µM and has short microsomal half-lives in mouse (23 min) and human (28 min). At 0-60 µM for 24 hours, it inhibits nucleotide excision repair (NER) with an IC50 of 15.6 µM in A375 cells and enhances cisplatin activity without toxicity. Additionally, at 10 µM for 6 hours, it delays DNA repair, indicated by an increase in γH2AX foci per cell[1].

Chemical Properties

Molecular Weight	326.17
Formula	C₁₅H₁₃Cl₂NO₃
Cas No.	1808986-37-9
Smiles	Oc1ccc(CNC(=O)Cc2ccc(Cl)cc2Cl)cc1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (689.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0659 mL	15.3294 mL	30.6589 mL	153.2943 mL
5 mM	0.6132 mL	3.0659 mL	6.1318 mL	30.6589 mL
10 mM	0.3066 mL	1.5329 mL	3.0659 mL	15.3294 mL
20 mM	0.1533 mL	0.7665 mL	1.5329 mL	7.6647 mL
50 mM	0.0613 mL	0.3066 mL	0.6132 mL	3.0659 mL
100 mM	0.0307 mL	0.1533 mL	0.3066 mL	1.5329 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc