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(E)-[6]-Dehydroparadol

🥰Excellent
Catalog No. T13436Cas No. 878006-06-5
Alias (6)-Dehydroparadol

(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.

(E)-[6]-Dehydroparadol
Other Forms of (E)-[6]-Dehydroparadol:
ParadolT711327113-22-0
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(E)-[6]-Dehydroparadol

🥰Excellent
Purity: 99.85%
Catalog No. T13436Alias (6)-DehydroparadolCas No. 878006-06-5
(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.
Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
5 mg$85In Stock
10 mg$118In Stock
25 mg$218In Stock
50 mg$297In Stock
100 mg$428In Stock
500 mg$968In Stock
1 mL x 10 mM (in DMSO)$94In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.85%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.
Targets&IC50
HCT116 cells:41.59 μM , HCT116 cells:43.02 μM
In vitro
(E)-[6]-Dehydroparadol (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 µM, respectively. (E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells[1].
In vivo
(E)-[6]-Dehydroparadol at a concentration of 5 µM for 24 hours increases the fluorescence signal of Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] in Tg(gstp1:GFP) transgenic zebrafish embryos.
Synonyms(6)-Dehydroparadol
Chemical Properties
Molecular Weight276.37
FormulaC17H24O3
Cas No.878006-06-5
SmilesCCCCCCCC(=O)\C=C\c1ccc(O)c(OC)c1
Relative Density.1.040 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (434.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6183 mL18.0917 mL36.1834 mL180.9169 mL
5 mM0.7237 mL3.6183 mL7.2367 mL36.1834 mL
10 mM0.3618 mL1.8092 mL3.6183 mL18.0917 mL
20 mM0.1809 mL0.9046 mL1.8092 mL9.0458 mL
50 mM0.0724 mL0.3618 mL0.7237 mL3.6183 mL
100 mM0.0362 mL0.1809 mL0.3618 mL1.8092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nrf2HCT-116[6]-Dehydroparadol
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