DCLK1 Protein, Human, Recombinant (aa 266-740, GST)

Catalog No. TMPC-00213 Copy Product Info

DCLK1 Protein, Human, Recombinant (aa 266-740, GST) is expressed in Baculovirus-Insect Cells. The accession number is O15075.

DCLK1 Protein, Human, Recombinant (aa 266-740, GST)

Catalog No. TMPC-00213

Copy Product Info

DCLK1 Protein, Human, Recombinant (aa 266-740, GST) is expressed in Baculovirus-Insect Cells. The accession number is O15075.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 μg	$1,390	35 days	35 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of DCAMKL1 was determined to be 2-3 nmol /min/mg by radioactive kinase assay.
Description	DCLK1 Protein, Human, Recombinant (aa 266-740, GST) is expressed in Baculovirus-Insect Cells. The accession number is O15075.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	O15075
Synonyms	Serine/threonine-protein kinase DCLK1,KIAA0369,DCLK1,DCDC3A,DCAMKL1
Construction	Recombinant human DCAMKL1 (266-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Molecular Weight	~80 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.