Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
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Description | CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively. |
Targets&IC50 | CDK9:39.5 nM (IC50), CDK6:40.5 nM (IC50) |
In vitro | Treatment with CDK6/9-IN-1 (Compound 66, at concentrations of 4 or 8 μM in MDA-MB-231 cells) results in G0/G1 cell cycle arrest, with arrest rates of 71.85% and 77.51%, respectively, compared to the control group's rate of 57.65%[1]. |
In vivo | Compound 66 (CDK6/9-IN-1) markedly reduces tumor growth in a xenograft mouse model without apparent toxicity. This underscores the promising potential of CDK6/9 dual inhibitors as a therapeutic option for cancer treatment[1]. |
Synonyms | CDK6/9-IN-1 |
Molecular Weight | 452.95 |
Formula | C22H25ClN8O |
CAS No. | 2414373-55-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CDK6/9-IN-1 2414373-55-8 CDK-6/9-IN-1 CDK6/9 IN 1 CDK6/9IN1 inhibitor inhibit