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CDK6/9-IN-1

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Catalog No. T40047Cas No. 2414373-55-8
Alias CDK6/9-IN-1

CDK6/9-IN-1 (compound 66) is a potent, orally administered dual inhibitor of CDK6 and CDK9, with IC50 values of 40.5 nM and 39.5 nM, respectively.

CDK6/9-IN-1

CDK6/9-IN-1

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Catalog No. T40047Alias CDK6/9-IN-1Cas No. 2414373-55-8
CDK6/9-IN-1 (compound 66) is a potent, orally administered dual inhibitor of CDK6 and CDK9, with IC50 values of 40.5 nM and 39.5 nM, respectively.
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5 mg$970InquiryInquiry
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Product Introduction

Bioactivity
Description
CDK6/9-IN-1 (compound 66) is a potent, orally administered dual inhibitor of CDK6 and CDK9, with IC50 values of 40.5 nM and 39.5 nM, respectively.
Targets&IC50
CDK9:39.5 nM (IC50), CDK6:40.5 nM (IC50)
In vitro
Treatment with CDK6/9-IN-1 (Compound 66, at concentrations of 4 or 8 μM in MDA-MB-231 cells) results in G0/G1 cell cycle arrest, with arrest rates of 71.85% and 77.51%, respectively, compared to the control group's rate of 57.65%[1].
In vivo
Compound 66 (CDK6/9-IN-1) markedly reduces tumor growth in a xenograft mouse model without apparent toxicity. This underscores the promising potential of CDK6/9 dual inhibitors as a therapeutic option for cancer treatment[1].
SynonymsCDK6/9-IN-1
Chemical Properties
Molecular Weight452.95
FormulaC22H25ClN8O
Cas No.2414373-55-8
SmilesCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(C)=O)c3)n2)nc1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CDK-6/9-IN-1CDK6/9IN1CDK6/9 IN 1
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