Anti-Phospho-PERK (Thr980) Polyclonal Antibody

Name: Anti-Phospho-PERK (Thr980) Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01476
Rating: 4.5 (1 reviews)

(Synonyms: WRS, PRKR-like endoplasmic reticulum kinase, p-PERK (Thr980), p-PERK (T980), PERK (p-Thr980), PERK (p-T980), PEK, Pancreatic eIF2-alpha kinase, Pancreatic eIF2 alpha kinase, HsPEK, HRI, Heme regulated EIF2 alpha kinase, Eukaryotic translation initiation factor 2 alpha kinase 3, EIF2AK3, EC 2.7.11.1, E2AK3, DKFZp781H1925) Copy Product Info

🥰Excellent

Synonyms: WRS, PRKR-like endoplasmic reticulum kinase, p-PERK (Thr980), p-PERK (T980), PERK (p-Thr980), PERK (p-T980), PEK, Pancreatic eIF2-alpha kinase, Pancreatic eIF2 alpha kinase, HsPEK, HRI, Heme regulated EIF2 alpha kinase, Eukaryotic translation initiation factor 2 alpha kinase 3, EIF2AK3, EC 2.7.11.1, E2AK3, DKFZp781H1925

Catalog No. TMAB-01476 Copy Product Info

🥰Excellent

Anti-Phospho-PERK (Thr980) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PERK (Thr980). Anti-Phospho-PERK (Thr980) Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P.

Anti-Phospho-PERK
(Thr980) Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-Phospho-PERK (Thr980) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PERK (Thr980). Anti-Phospho-PERK (Thr980) Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P.
Synonyms	WRS, PRKR-like endoplasmic reticulum kinase, p-PERK (Thr980), p-PERK (T980), PERK (p-Thr980), PERK (p-T980), PEK, Pancreatic eIF2-alpha kinase, Pancreatic eIF2 alpha kinase, HsPEK, HRI, Heme regulated EIF2 alpha kinase, Eukaryotic translation initiation factor 2 alpha kinase 3, EIF2AK3, EC 2.7.11.1, E2AK3, DKFZp781H1925
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Rabbit)

Application	FCM ICC/IF IF IHC-Fr IHC-P
Recommended Dose	FCM=1 μg/Test; ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].

Antigen Details

Immunogen	KLH conjugated synthesised phosphopeptide: human PERK around the phosphorylation site of Thr980
Antigen Species	Human
Gene Name	EIF2AK3
Gene ID	9451
Protein Name	Eukaryotic translation initiation factor 2-alpha kinase 3
Uniprot ID	Q9NZJ5
Biology Area	Regulation,Eukaryotic Initiation factors (eIF's),Diabetes,Metabolic disorders,Obesity
Function	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:9930704, PubMed:11106749, PubMed:23921556).Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (PubMed:9930704, PubMed:11106749, PubMed:23921556).EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:11106749, PubMed:23921556).Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797).Involved in control of mitochondrial morphology and function (PubMed:23921556).