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Lignans

The lignans are a group of chemical compounds possessing a steroid-like chemical structure found in plants, particularly in flax seed. Lignans are one of the major classes of phytoestrogens, which are estrogen-like chemicals and also act as antioxidants. The other classes of phytoestrogens are the isoflavones, and coumestans. Traditionally, health benefits attributed to lignans have included a lowered risk of heart disease, menopausal symptoms, osteoporosis and breast cancer.

  • Etoposide
    T013233419-42-0
    Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
    • $33
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  • Angeloylgomisin Q
    TN139072561-28-5
    Angeloylgomisin Q is a natural product from Schizandra chinensis BAILL.
    • $190
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  • Eleutheroside E
    T366239432-56-9
    Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the generation of TNF-α and IL-6, the m
    • $35
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  • magnolin
    T385731008-18-1
    Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
    • $93
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  • Alashinol G
    TN708958139-12-1
    Alashinol G ((-)-Carinol) is isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects.
    • $148
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  • DL-Syringaresinol
    TN15941177-14-6
    DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin aging through autophagy, alleviate oxaliplatin-induced neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses.
    • $196
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  • Dihydrodehydrodiconiferyl alcohol
    TN384928199-69-1
    Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
    • $173
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  • Picropodophyllol
    TN20703811-15-2
    Picropodophyllol is a natural product isolated from the roots of Dysosma versipellis
    • $57
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  • Asperphenamate
    T1039063631-36-7In house
    Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.
    • $112
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  • Eudesmin
    T3836526-06-7
    Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.
    • $142
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  • Picropodophyllin
    T6943477-47-4
    Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast stem cell growth factor (KIT).
    • $58
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  • Styraxlignolide F
    TN2241823214-06-8
    3-Hydroxymandelic Acid is a metabolite of Phenylephrine. 3-Hydroxymandelic Acid is a metabolite of Phenylephrine, which is an α-receptor agonist.
    • $129
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  • Matairesinol 4′-O-β-D-glucopyranoside
    TN1915106647-14-7
    Matairesinol 4′-O-β-D-glucopyranoside is a natural product isolated from Trachelospermum jasminoides.
    • $133
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  • Isoasatone A
    T1168067451-73-4
    Isoasatone A is a natural product isolated from the plant Heterotropa takaoi M., with anti-insect activity.
    • $56
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  • L-asarinin
    T3765133-05-1
    L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft heart survival.
    • $140
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  • Gomisin O
    TN170972960-22-6
    Gomisin O (5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-ol) is a natural product from Schizandra chinensis.
    • $98
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  • Nortrachelogenin
    TN467534444-37-6
    Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl asparagin-dependent apoptosis.
    • $106
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  • Trachelogenin
    TN650834209-69-3
    Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway. chemical and concentration-dependent. Trachelogenin has antiviral, anti-inflammatory and analgesic activities with IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively.
    • $139
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  • Epimagnolin B
    TN10091134188-26-3
    Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.
    • $152
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  • Schisandrone
    TN111698619-25-1
    Schisandrone (Arisantetralone C) is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.
    • $58
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  • Hypophyllanthin
    TN175733676-00-5
    Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
    • $98
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  • 7,7'-Dihydrotaiwanin C
    TN6282216955-79-2
    7,7'-Dihydrotaiwanin C (1,4-Dihydrotaiwanin C) is a phytogenic antineoplastic agent isolated from Chamaecyparis formosensis.
    • $2,050
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  • Nortrachelogenin-8'-O-beta-glucoside
    TN4674858127-38-5
    Nortrachelogenin-8'-O-beta-glucoside is a lignan with a diarylhydroxybutyrolactone skeleton which isolated from the leaves and stems of Trachelospermum jasminoides (Lindl.) Lem.
    • $123
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  • Gomisin G
    TQ021762956-48-3
    Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
    • $64
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  • Schisandrol B
    T6S191758546-54-6
    1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.
    • $65
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  • 4'-Demethylpodophyllotoxin
    T2S002940505-27-9
    4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.
    • $39
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  • Dehydrodiisoeugenol
    T6S15432680-81-1
    1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated phosphorylation-dependent proteolys
    • $30
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  • Picropodophyllone
    TN2071477-48-5
    Picropodophyllone is one of the lignans from the roots of D. aurantiocaulis and D. pleianthum.
    • $40
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  • Podophyllotoxone
    T8188477-49-6
    Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
    • $35
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  • Angeloylgomisin H
    TN101866056-22-2
    Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug mL against MCF7, HEK293 and CAL27 cell lines.
    • $84
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  • Pinoresinol
    TN2080487-36-5
    Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1 Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1).
    • $52
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  • Secoisolariciresinol
    TN219729388-59-8
    Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes.
    • $129
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  • paulownin
    T569113040-46-5
    Paulownin, a furofuran lignan from Paulownia tomentosa,has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity.
    • $64
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  • Licarin B
    T4S154551020-87-2
    1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
    • $33
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  • Picropodophyllotoxin
    T3S002717434-18-3
    Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.
    • $32
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  • (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside
    T5S0483136997-64-3
    (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside ((-)-Syringaresnol-4-O-beta-D-apiofuranos) is a lignan glycosides from the bark of Albizzia myriophylla.
    • $139
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  • Taiwanin C
    TN628414944-34-4
    Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.
    • $1,850
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  • Schisanhenol
    T6S193069363-14-0
    1. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanhenol has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation.
    • $47
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  • Tetrahydromagnolol
    TN226820601-85-8
    Tetrahydromagnolol can activate cannabinoid (CB) receptors.
    • $50
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  • (Iso) (-)-Zuonin A
    T3S1541178740-32-4
    Rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydrofuran is a chemical component found in the fruit of nutmeg.
    • $57
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  • Asatone
    T1038338451-63-7
    Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK, and p38) pathways.
    • $90
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  • Gomisin J
    T390466280-25-9
    Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+ calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.
    • $39
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  • Deoxypodophyllotoxin
    TN108719186-35-7
    Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
    • $116
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  • Epimagnolin A
    TN161041689-51-4
    Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.
    • $113
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  • Niranthin
    TN466050656-77-4
    Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.
    • $198
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  • Macelignan
    T3866107534-93-0
    Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.
    • $100
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  • Tracheloside
    T385533464-71-0
    Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).
    • $44
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  • Sesamolin
    T5S2283526-07-8
    1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can significantly attenuate the excess g
    • $31
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  • Fargesin
    T5S217831008-19-2
    1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating Akt and AMPK in WAT.
    • $64
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  • Gomisin N
    T829769176-52-9
    Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy and inhibits proliferation and induces apoptosis in cancer.
    • $43
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