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Anti-HACE1 Polyclonal Antibody

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Catalog No. TMAB-06872

Anti-HACE1 Polyclonal Antibody is a Rabbit antibody targeting HACE1. Anti-HACE1 Polyclonal Antibody can be used in FCM.

Anti-HACE1 Polyclonal Antibody

Anti-HACE1 Polyclonal Antibody

😃Good
Catalog No. TMAB-06872
Anti-HACE1 Polyclonal Antibody is a Rabbit antibody targeting HACE1. Anti-HACE1 Polyclonal Antibody can be used in FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-HACE1 Polyclonal Antibody is a Rabbit antibody targeting HACE1. Anti-HACE1 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse)
Application
Recommended Dose
FCM: 2μg/Test
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum.
Tissue SpecificityExpressed in multiple tissues including heart, brain and kidney.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human HACE1
Antigen Species
Human
Gene Name
HACE1
Gene ID
Protein Name
E3 ubiquitin-protein ligase HACE1
Uniprot ID
Function
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Chemical Properties
Molecular WeightTheoretical: 90-102 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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