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Fluticasone furoate

Name: Fluticasone furoate
Brand: TargetMol
SKU: T21404
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21404Cas No. 397864-44-7

Alias Veramyst, Fluticasone furoate, Avamys, Allermist

Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.

Fluticasone furoate

🥰Excellent

Purity: 99.82%

Catalog No. T21404Alias Veramyst, Fluticasone furoate, Avamys, AllermistCas No. 397864-44-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$84	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$197	In Stock	In Stock
200 mg	$293	In Stock	In Stock
500 mg	$497	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.
Targets&IC50	Corticosteroid:0.3 nM (Kd)
In vitro	Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimuli[2].
In vivo	Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme CYP3A4 that converts the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potency[2].
Synonyms	Veramyst, Fluticasone furoate, Avamys, Allermist

Chemical Properties

Molecular Weight	538.58
Formula	C₂₇H₂₉F₃O₆S
Cas No.	397864-44-7
Smiles	[H][C@@]12C[C@@H](C)[C@](OC(=O)c3ccco3)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 95 mg/mL (176.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8567 mL	9.2837 mL	18.5673 mL	92.8367 mL
5 mM	0.3713 mL	1.8567 mL	3.7135 mL	18.5673 mL
10 mM	0.1857 mL	0.9284 mL	1.8567 mL	9.2837 mL
20 mM	0.0928 mL	0.4642 mL	0.9284 mL	4.6418 mL
50 mM	0.0371 mL	0.1857 mL	0.3713 mL	1.8567 mL
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9284 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc