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LIMK-IN-22j

Name: LIMK-IN-22j
Brand: TargetMol
SKU: T24410
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24410Cas No. 1116571-01-7

Alias LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22j

LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.

LIMK-IN-22j

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Purity: 99.16%

Catalog No. T24410Alias LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22jCas No. 1116571-01-7

LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$41	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$153	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.16%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

LIMK-IN-22j AI Summary

LIMK-IN-22j exhibits potent inhibition of human recombinant LIMK2 with an IC50 of 0.9 nM and LIMK1 with an IC50 of 0.5 nM. It shows moderate inhibition of LIMK2 in pig PTM cells, reducing cofilin-phosphorylation by 50% at 10 nM. In a mouse model, it demonstrates activity against dexamethasone-induced ocular hypertension, reducing intraocular pressure by 3.7 mmHg within 1 hour at a dose of 5 µg. LIMK-IN-22j is selective towards LIMK2 over ROCK1 and ROCK2, with IC50 ratios greater than 100 and 900, respectively. Additionally, it enhances outflow facility in pig eyes by 30% at a concentration of 100 nM, as evidenced by an eye-perfusion assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.
Targets&IC50	LIMK1:0.9 nM, ROCK2:2700 nM, ROCK1:260 nM, LIMK2:0.5 nM
Synonyms	LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22j

Chemical Properties

Molecular Weight	453.34
Formula	C₂₀H₂₁BrN₈
Cas No.	1116571-01-7
Smiles	C[C@H]1CN(CCN1\C(Nc1cccc(Br)c1)=N\C#N)c1ncnc2[nH]cc(C)c12
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (121.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2058 mL	11.0292 mL	22.0585 mL	110.2925 mL
5 mM	0.4412 mL	2.2058 mL	4.4117 mL	22.0585 mL
10 mM	0.2206 mL	1.1029 mL	2.2058 mL	11.0292 mL
20 mM	0.1103 mL	0.5515 mL	1.1029 mL	5.5146 mL
50 mM	0.0441 mL	0.2206 mL	0.4412 mL	2.2058 mL
100 mM	0.0221 mL	0.1103 mL	0.2206 mL	1.1029 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc