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Anti-AIF Polyclonal Antibody
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Catalog No. TMAB-00082
Alias Programmed Cell Death Protein 8, PDCD8, Apoptosis-Inducing Factor 1 Mitochondrial, AIFM1, AIF
Anti-AIF Polyclonal Antibody is a Rabbit antibody targeting AIF. Anti-AIF Polyclonal Antibody can be used in WB.
Anti-AIF Polyclonal Antibody
Anti-AIF Polyclonal Antibody
😃Good
Catalog No. TMAB-00082Alias Programmed Cell Death Protein 8, PDCD8, Apoptosis-Inducing Factor 1 Mitochondrial, AIFM1, AIF
Anti-AIF Polyclonal Antibody is a Rabbit antibody targeting AIF. Anti-AIF Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-AIF Polyclonal Antibody is a Rabbit antibody targeting AIF. Anti-AIF Polyclonal Antibody can be used in WB. |
| Alias | Programmed Cell Death Protein 8, PDCD8, Apoptosis-Inducing Factor 1 Mitochondrial, AIFM1, AIF |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat,Pig (predicted:Chicken,Dog,Cow,Rabbit,Sheep) |
| Verified Activity | 1. Sample: Lane 1: K562 (Human) Cell Lysate at 30 μg Lane 2: Testis (Rat) Lysate at 40 μg Lane 3: Testis (Mouse) Lysate at 40 μg Primary: Anti-AIF (TMAB-00082) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67/62/57 kDa Observed band size: 62 kDa 2. Sample: Liver (Mouse) Lysate at 40 μg Primary: Anti-AIF at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kDa Observed band size: 63 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]. |
| Immunogen | KLH conjugated synthetic peptide: human AIF |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Metabolism,Chromatin condensation,Chromatin condensation,Chromatin Condensation,Nuclear,Apoptosis,Oxidative stress |
| Molecular Weight | Theoretical: 57 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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