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Anti-AIF Polyclonal Antibody

😃Good
Catalog No. TMAB-00082
Alias Programmed Cell Death Protein 8, PDCD8, Apoptosis-Inducing Factor 1 Mitochondrial, AIFM1, AIF

Anti-AIF Polyclonal Antibody is a Rabbit antibody targeting AIF. Anti-AIF Polyclonal Antibody can be used in WB.

Anti-AIF Polyclonal Antibody

Anti-AIF Polyclonal Antibody

😃Good
Catalog No. TMAB-00082Alias Programmed Cell Death Protein 8, PDCD8, Apoptosis-Inducing Factor 1 Mitochondrial, AIFM1, AIF
Anti-AIF Polyclonal Antibody is a Rabbit antibody targeting AIF. Anti-AIF Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3727-10 days
200 μL$5277-10 days
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Product Introduction

Bioactivity
Description
Anti-AIF Polyclonal Antibody is a Rabbit antibody targeting AIF. Anti-AIF Polyclonal Antibody can be used in WB.
AliasProgrammed Cell Death Protein 8, PDCD8, Apoptosis-Inducing Factor 1 Mitochondrial, AIFM1, AIF
Ig Type
IgG
Reactivity
Human,Mouse,Rat,Pig (predicted:Chicken,Dog,Cow,Rabbit,Sheep)
Verified Activity
1. Sample:
Lane 1: K562 (Human) Cell Lysate at 30 μg
Lane 2: Testis (Rat) Lysate at 40 μg
Lane 3: Testis (Mouse) Lysate at 40 μg
Primary: Anti-AIF (TMAB-00082) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 67/62/57 kDa
Observed band size: 62 kDa
2. Sample:
Liver (Mouse) Lysate at 40 μg
Primary: Anti-AIF at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 57 kDa
Observed band size: 63 kDa
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundThis gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human AIF
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
Metabolism,Chromatin condensation,Chromatin condensation,Chromatin Condensation,Nuclear,Apoptosis,Oxidative stress
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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