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Elagolix sodium

Name: Elagolix sodium
Brand: TargetMol
SKU: T5031
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5031Cas No. 832720-36-2

Alias NBI-56418 sodium

Elagolix sodium (NBI-56418 sodium) is a GnRH receptor (GnRHR) antagonist ( IC50 and Ki of 0.25 and 3.7 nM, respectively).

Elagolix sodium

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Purity: 99.71%

Catalog No. T5031Alias NBI-56418 sodiumCas No. 832720-36-2

Elagolix sodium (NBI-56418 sodium) is a GnRH receptor (GnRHR) antagonist ( IC50 and Ki of 0.25 and 3.7 nM, respectively).

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$73	In Stock
25 mg	$147	In Stock
50 mg	$239	In Stock
100 mg	$378	In Stock
200 mg	$559	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock

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Batch Information

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Purity:99.71%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Elagolix sodium (NBI-56418 sodium) is a GnRH receptor (GnRHR) antagonist ( IC50 and Ki of 0.25 and 3.7 nM, respectively).
Targets&IC50	GnRHR:3.7 nM, NFAT:5.4 nM
In vivo	Elagolix sodium for the treatment of women with moderate to severe endometriosis-associated pain[1]
Synonyms	NBI-56418 sodium

Chemical Properties

Molecular Weight	653.57
Formula	C₃₂H₂₉F₅N₃NaO₅
Cas No.	832720-36-2
Smiles	[Na+].COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](NCCCC([O-])=O)c2ccccc2)c1=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (76.5 mM), Sonication is recommended.

H2O: 50 mg/mL (76.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.5301 mL	7.6503 mL	15.3006 mL	76.5029 mL
5 mM	0.3060 mL	1.5301 mL	3.0601 mL	15.3006 mL
10 mM	0.1530 mL	0.7650 mL	1.5301 mL	7.6503 mL
20 mM	0.0765 mL	0.3825 mL	0.7650 mL	3.8251 mL
50 mM	0.0306 mL	0.1530 mL	0.3060 mL	1.5301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc