Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

N-Desmethyl Sildenafil

Copy Product Info
😃Good
Catalog No. T36061Cas No. 139755-82-1
Alias UK-103,320, Desmethylsildenafil

N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.

N-Desmethyl Sildenafil
Other Forms of N-Desmethyl Sildenafil:

N-Desmethyl Sildenafil

Copy Product Info
😃Good
Purity: 99.35%
Catalog No. T36061Alias UK-103,320, DesmethylsildenafilCas No. 139755-82-1
N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$46In StockIn Stock
10 mg$75In StockIn Stock
25 mg$153In StockIn Stock
50 mg$245In StockIn Stock
100 mg$357In StockIn Stock
200 mg$529-In Stock
1 mL x 10 mM (in DMSO)$51In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.35%
Appearance:Solid
Color:White
Contact us for more batch information

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity
Description
N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
In vitro
N-Desmethyl Sildenafil enhances the amplitude of electroretinogram (ERG) signals from dark-adapted isolated rat retinas, likely by improving photoreceptor cell responses[1]. This compound's formation is investigated through the use of CYP3A supersomes that co-express human P450 oxidoreductase and cytochrome b5, with its synthesis being predominantly catalyzed by CYP3A4 and CYP3A5 enzymes, and to a smaller degree by CYP3A7[2].
SynonymsUK-103,320, Desmethylsildenafil
Chemical Properties
Molecular Weight460.55
FormulaC21H28N6O4S
Cas No.139755-82-1
SmilesCCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 5 mg/mL (10.86 mM), Sonication is recommended.
DMSO:PBS (pH 7.2)(1:5): 0.15 mg/mL (0.33 mM), Sonication is recommended.
DMSO: 225 mg/mL (488.55 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.86 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-Desmethyl SildenafilDrugMetaboliteDrug Metabolite
Related Tags: buy N-Desmethyl Sildenafil | purchase N-Desmethyl Sildenafil | N-Desmethyl Sildenafil cost | order N-Desmethyl Sildenafil | N-Desmethyl Sildenafil chemical structure | N-Desmethyl Sildenafil in vitro | N-Desmethyl Sildenafil formula | N-Desmethyl Sildenafil molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.