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VPC-14449

Name: VPC-14449
Brand: TargetMol
SKU: T24944
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24944Cas No. 1621375-32-3

Alias VPC14449

VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.

VPC-14449

🥰Excellent

Purity: 99.56%

Catalog No. T24944Alias VPC14449Cas No. 1621375-32-3

VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$127	In Stock	In Stock
25 mg	$269	In Stock	In Stock
50 mg	$432	In Stock	In Stock
100 mg	$689	-	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.
Targets&IC50	AR-DBD:0.34 μM
In vitro	Methods: LNCaP, C4-2, MR49F, and 22Rv1 cells were treated with VPC-14449 (0.01-100 μM, 24 hours) to test its inhibitory effect on AR-V7 transcriptional activity in cells. Results: VPC-14449 inhibited AR transcriptional activity and cell viability in LNCaP, C4-2, MR49F, and 22Rv1 cells.[1]
In vivo	Methods: Castrated mice were given VPC-14449 (100 mg/kg, ip, for 4 weeks) twice daily and LNCaP xenograft tumor volume and serum PSA were assessed. Results: VPC-14449 reduced tumor volume and abolished PSA production in the LNCaP xenograft model.[1]
Synonyms	VPC14449

Chemical Properties

Molecular Weight	394.09
Formula	C₁₀H₁₀Br₂N₄OS
Cas No.	1621375-32-3
Smiles	BrC=1N=C(Br)N(C1)C=2N=C(SC2)N3CCOCC3
Relative Density.	2.12 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (253.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5375 mL	12.6875 mL	25.3749 mL	126.8746 mL
5 mM	0.5075 mL	2.5375 mL	5.0750 mL	25.3749 mL
10 mM	0.2537 mL	1.2687 mL	2.5375 mL	12.6875 mL
20 mM	0.1269 mL	0.6344 mL	1.2687 mL	6.3437 mL
50 mM	0.0507 mL	0.2537 mL	0.5075 mL	2.5375 mL
100 mM	0.0254 mL	0.1269 mL	0.2537 mL	1.2687 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc