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Glycogen phosphorylase-IN-1

🥰Excellent
Catalog No. T37577Cas No. 648926-15-2

Glycogen phosphorylase-IN-1 is a selective and potent inhibitor of human hepatic glycogen phosphorylase (hlGPa) with inhibitory effects on hlGPa activity and on hepatocyte glycogen-derived glucose production, and can be used in the study of type 2 diabetes mellitus and canine lupus.

Glycogen phosphorylase-IN-1

Glycogen phosphorylase-IN-1

🥰Excellent
Purity: 98.15%
Catalog No. T37577Cas No. 648926-15-2
Glycogen phosphorylase-IN-1 is a selective and potent inhibitor of human hepatic glycogen phosphorylase (hlGPa) with inhibitory effects on hlGPa activity and on hepatocyte glycogen-derived glucose production, and can be used in the study of type 2 diabetes mellitus and canine lupus.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$229In StockIn Stock
5 mg$688In StockIn Stock
10 mg$983In StockIn Stock
25 mg$1,460In StockIn Stock
50 mg$1,960In StockIn Stock
100 mg$2,650In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.15%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Glycogen phosphorylase-IN-1 is a selective and potent inhibitor of human hepatic glycogen phosphorylase (hlGPa) with inhibitory effects on hlGPa activity and on hepatocyte glycogen-derived glucose production, and can be used in the study of type 2 diabetes mellitus and canine lupus.
In vivo
In the glucagon-stimulated hyperglycemia model in Wistar rats, Glycogen phosphorylase-IN-1 (5 mg/kg; administered via intravenous injection, single dose) was able to reduce blood glucose levels[1].
Chemical Properties
Molecular Weight412.78
FormulaC17H15ClF2N4O4
Cas No.648926-15-2
SmilesO=C(NC(=O)C1=CC(F)=C(F)C=C1Cl)NC2=CC(=CC=C2OC)NC(=O)NC
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 2 mg/mL (4.85 mM), Sonication is recommended.
DMSO: 2 mg/mL (4.85 mM), Sonication is recommended.
Solution Preparation Table
DMF/DMSO
1mg5mg10mg50mg
1 mM2.4226 mL12.1130 mL24.2260 mL121.1299 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Glycogen Phosphorylase InhibitorGlycogen phosphorylase (GP)
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