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PF-4878691
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Catalog No. T16506Cas No. 532959-63-0
Alias 3M-852A
PF-4878691 (3M-852A) is a potent and selective Toll-like receptor 7 agonist, designed to dissociate its antiviral and inflammatory activities.
PF-4878691
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Purity: 98.43%
Catalog No. T16506Alias 3M-852ACas No. 532959-63-0
PF-4878691 (3M-852A) is a potent and selective Toll-like receptor 7 agonist, designed to dissociate its antiviral and inflammatory activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | In Stock | In Stock | |
| 5 mg | $147 | In Stock | In Stock | |
| 10 mg | $247 | In Stock | In Stock | |
| 25 mg | $496 | In Stock | In Stock | |
| 50 mg | $795 | In Stock | In Stock | |
| 100 mg | $1,260 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $162 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.43%
Appearance:Solid
Color:White
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Product Introduction
PF-4878691 AI Summary
PF-4878691 exhibits diverse pharmacokinetic and pharmacodynamic properties, including a volume of distribution at steady state of 3.1 L.kg-1, clearance of 7.7 mL.min-1.kg-1, mean residence time of 4.7 hours, and a half-life of 7.1 hours when administered intravenously at a dose of 2 mg. The compound demonstrates antitumor activity in mouse HM1 cells xenografted in B6C3F1 mice, with inhibition of lung metastasis observed at both 1 mg/kg and 10 mg/kg doses, achieving a higher inhibition rate of 55.0% at 10 mg/kg. Additionally, it increases IFN levels in Balb/c mouse plasma at 10 mg/kg and functions as an agonist at TLR7 in both mouse and human models, with EC50 values of 6224.0 nM and 2657.0 nM, respectively. Pharmacokinetic data show a plasma protein binding (PPB) of 66.61%, high solubility of 537,000.0 nM in pH 7.4 buffer, and a LogD7.4 value of 1.24. The compound also displays antiviral activities, with an EC50 value of 100000.0 nM against Hepatitis C Virus (HCV) and an IC50 value greater than 20000.0 nM against SARS-CoV-2. These properties mark PF-4878691 as a candidate with potential therapeutic applications, subject to further optimization and evaluation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PF-4878691 (3M-852A) is a potent and selective Toll-like receptor 7 agonist, designed to dissociate its antiviral and inflammatory activities. |
| Synonyms | 3M-852A |
| Molecular Weight | 361.46 |
| Formula | C17H23N5O2S |
| Cas No. | 532959-63-0 |
| Smiles | CCc1nc2c(N)nc3ccccc3c2n1CCCCNS(C)(=O)=O |
| Relative Density. | 1.38 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 19.23 mg/mL (53.2 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.5 mg/mL (4.15 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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