Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+). It effectively discriminates against and exterminates G+ by interacting with lipoteichoic acids (LTA), displaying robust antibacterial activity under light irradiation [1].

The antibacterial agent 140 chloride (0.1-5 µg/mL, 1 h) showed dose-dependent dark toxicity against S. aureus, with inhibition ranging from 78% to 0% [1]. Exposure to light for 120 seconds significantly enhanced its efficacy, with nearly complete inhibition of S. aureus growth at very low concentrations [1]. Additionally, over 80% of HeLa cells survived after treatment with antibacterial agent 140 chloride (0.1-5 µg/mL, 1 h), and more than 73% remained viable under light conditions at concentrations ≤32 µM [1].

Antibacterial agent 140 chloride (20 μg/mL/50 μL; 1-10 days) significantly reduced the size of Staphylococcus aureus-induced wound infections, with wounds in female Kunming mice nearly fully healed after 7 days.