Shopping Cart
Remove All
Your shopping cart is currently empty
CPI-637
😃Good
Catalog No. T6811Cas No. 1884712-47-3
Alias CPI 637
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
CPI-637
😃Good
Purity: 99.95%
Catalog No. T6811Alias CPI 637Cas No. 1884712-47-3
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $34 | In Stock | In Stock | |
| 2 mg | $47 | In Stock | In Stock | |
| 5 mg | $71 | In Stock | In Stock | |
| 10 mg | $102 | In Stock | In Stock | |
| 25 mg | $223 | In Stock | In Stock | |
| 50 mg | $397 | In Stock | In Stock | |
| 100 mg | $597 | - | In Stock | |
| 500 mg | $1,260 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.95%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. |
| Targets&IC50 | CBP:0.03 μM, EP300:0.051 μM, BRD4 BD1:11 μM |
| In vitro | CPI-637 inhibits MYC expression in AMO-1 cells (EC50=0.60 μM)[1]. |
| Kinase Assay | Ki Determination: Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis. |
| Cell Research | AMO-1 cells (DSMZ) were plated at 20,000 cells/well in 96-well plates in Iscove's Modified Dulbecco's Medium supplemented with 10% fetal calf serum. Cells were treated for 6 h with a dose titration of CPI-637 starting from a 5 μM top concentration. After 6 h, cells were lysed and processed for QuantiGene Plex expression analysis and data were collected on a MAGPIX multiplex Luminex instrument.(Only for Reference) |
| Synonyms | CPI 637 |
| Molecular Weight | 386.45 |
| Formula | C22H22N6O |
| Cas No. | 1884712-47-3 |
| Smiles | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1 |
| Relative Density. | 1.38 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.87 mg/mL (10.01 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy CPI-637 | purchase CPI-637 | CPI-637 cost | order CPI-637 | CPI-637 chemical structure | CPI-637 in vitro | CPI-637 formula | CPI-637 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.