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Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757)
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Catalog No. T9901A-508
Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) is a humanized antibody arm derived from the half-life extended bispecific T-cell engager (BiTE) AMG-757. This product specifically targets Delta-like ligand 3 (DLL3), a Notch pathway ligand highly expressed in small-cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It binds to the extracellular domain of DLL3 with picomolar (pM) affinity. In a bispecific format, it facilitates the redirection of T cells to DLL3-positive tumor cells, inducing T-cell activation and the release of cytotoxic granules to exert potent anti-tumor effects.
Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757)
Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757)
😃Good
Catalog No. T9901A-508
Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) is a humanized antibody arm derived from the half-life extended bispecific T-cell engager (BiTE) AMG-757. This product specifically targets Delta-like ligand 3 (DLL3), a Notch pathway ligand highly expressed in small-cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It binds to the extracellular domain of DLL3 with picomolar (pM) affinity. In a bispecific format, it facilitates the redirection of T cells to DLL3-positive tumor cells, inducing T-cell activation and the release of cytotoxic granules to exert potent anti-tumor effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $722 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $1,980 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $3,260 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) is a humanized antibody arm derived from the half-life extended bispecific T-cell engager (BiTE) AMG-757. This product specifically targets Delta-like ligand 3 (DLL3), a Notch pathway ligand highly expressed in small-cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It binds to the extracellular domain of DLL3 with picomolar (pM) affinity. In a bispecific format, it facilitates the redirection of T cells to DLL3-positive tumor cells, inducing T-cell activation and the release of cytotoxic granules to exert potent anti-tumor effects. |
| Targets&IC50 | DLL3 (human):0.64nM(Kd) |
| In vitro | The anti-DLL3 arm binds human DLL3 with high affinity (KD ≈ 0.64 nM). In T-cell and SCLC co-culture assays, the antibody redirects T cells, leading to robust activation (CD25/CD69 upregulation) and secretion of IFN-γ and TNF-α, which results in potent, dose-dependent lysis of DLL3-expressing tumor cells [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | DLL3 |
| Isotype | IgG1 |
| Storage | store at low temperature | Lyophilized powder: -20~-80°C for 1 year | Shipping with blue ice. |
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