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Isoindigotin
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Catalog No. T1840Cas No. 476-34-6
Isoindigotin is used in the therapy of Y.
Isoindigotin
Copy Product Info🥰Excellent
Purity: 98.96%
Catalog No. T1840Cas No. 476-34-6
Isoindigotin is used in the therapy of Y.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $29 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.96%
Appearance:Solid
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Product Introduction
Isoindigotin AI Summary
Isoindigotin exhibits a broad spectrum of bioactivities, including significant antiproliferative effects against various human tumor cell lines such as HL60, K562, and KB cells, with inhibitory percentages of 53.0%, 64.0%, and 92.0% at 10 µM after 72 hours, respectively. It has an IC50 value of 1600.0 nM for KB cells. In addition to its anticancer properties, it induces NQO1 and CYP1A1 activities in mouse Hepa-1c1c7 cells, showing a moderate induction at 0.1 µM after 48 hours by MTT and EROD assays. It also exhibits cytotoxicity against Hepa-1c1c7 cells over 48 hours. Isoindigotin acts as an inhibitor of human transglutaminase 2 with an IC50 value of 8000.0 nM and a Ki value of 41000.0 nM. Furthermore, it demonstrates growth inhibition activity across a variety of human tumor cell lines, including breast, renal, melanoma, lung, ovarian, prostate, colon, leukemia, and central nervous system cells, with GI50 values ranging from low to high nanomolar concentrations. Additionally, it has antimicrobial activity against Mycobacterium tuberculosis H37Rv in African green monkey Vero cells, with a MIC of 27000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Isoindigotin is used in the therapy of Y. |
| Molecular Weight | 262.26 |
| Formula | C16H10N2O2 |
| Cas No. | 476-34-6 |
| Smiles | O=C1Nc2ccccc2C1=C1C(=O)Nc2ccccc12 |
| Relative Density. | 1.417g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (34.32 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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