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L-Aspartic acid

Name: L-Aspartic acid
Brand: TargetMol
SKU: T2O2731
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2O2731Cas No. 56-84-8

Alias L-Aspartate, Aspatofort, Asparagic acid

L-Aspartic acid (Aspatofort) is a non-essential amino acid in humans, L-Aspartic acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. L-Aspartic acid also serves as a neurotransmitter.

L-Aspartic acid

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Purity: 99.80%

Catalog No. T2O2731Alias L-Aspartate, Aspatofort, Asparagic acidCas No. 56-84-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$41	In Stock	In Stock
1 g	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.80%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

L-Aspartic acid AI Summary

L-Aspartic acid exhibits a broad spectrum of bioactivity and physicochemical properties across various assays and biological systems. It activates multiple carbonic anhydrase isozymes, including human carbonic anhydrase I (KA 48.0 μM), II (KA 130.0 μM), and bovine carbonic anhydrase IV (KA 60.0 μM). It also activates Leishmania donovani chagasi carbonic anhydrase (KA 0.3 μM) and moderately activates Trypanosoma cruzi carbonic anhydrase (KA 18.7 μM). The compound shows agonistic activity at mGlu receptors (EC50 > 1,000,000 nM) and inhibits N-methyl-D-aspartate glutamate receptor binding with moderate potency (IC50 = 1638.0 nM). With a high partition coefficient (logP = 4.01) and a pKa of 9.67, L-Aspartic acid is lipophilic, suggesting good membrane permeability. It demonstrates uptake and growth reversal in various cell lines, including H4, MH1C1, and 7800C1 cells. Additionally, it shows 17.0% residue fraction and a half-life of 2.867 hours in ischemic myocardial tissue in dogs. In antiviral studies, it inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells (10 μM concentration) but shows limited efficacy in other SARS-CoV-2 assays. L-Aspartic acid modulates excitatory amino acid transporters (EAATs) and inhibits HDAC6, pyruvate carboxylase (Ki = 700.0 nM), and shows binding to sodium-coupled aspartate transporters (Kd = 1.0 - 94.0 nM). However, it has limited antiviral potency against SARS-CoV-2 in VERO-6 cells and other systems. Overall, L-Aspartic acid’s versatile bioactivity spectrum and lipophilic nature indicate potential applications in drug development targeting diverse biological systems and diseases, albeit with varying degrees of efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Aspartic acid (Aspatofort) is a non-essential amino acid in humans, L-Aspartic acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. L-Aspartic acid also serves as a neurotransmitter.
Synonyms	L-Aspartate, Aspatofort, Asparagic acid

Chemical Properties

Molecular Weight	133.1
Formula	C₄H₇NO₄
Cas No.	56-84-8
Smiles	[C@H](CC(O)=O)(C(O)=O)N
Relative Density.	1.66. Temperature:13 °C.;1.661. Temperature:13 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 8 mg/mL (60.11 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.5131 mL	37.5657 mL	75.1315 mL	375.6574 mL
5 mM	1.5026 mL	7.5131 mL	15.0263 mL	75.1315 mL
10 mM	0.7513 mL	3.7566 mL	7.5131 mL	37.5657 mL
20 mM	0.3757 mL	1.8783 mL	3.7566 mL	18.7829 mL
50 mM	0.1503 mL	0.7513 mL	1.5026 mL	7.5131 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc