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Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: TargetMol
SKU: T1470L
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1470LCas No. 138452-21-8

Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistaminic activity.

Fexofenadine hydrochloride

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Catalog No. T1470LCas No. 138452-21-8

Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistaminic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	-
25 mg	$68	In Stock	-
50 mg	$107	In Stock	-
100 mg	$143	Inquiry	Inquiry
200 mg	$201	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$48	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Fexofenadine hydrochloride AI Summary

Fexofenadine hydrochloride has shown a broad spectrum of bioactivities and pharmacokinetic properties. It exhibits potent antiplasmodial activity against Plasmodium falciparum W2 with an IC50 value of 10000.0 nM and demonstrates inhibitory effects on enzymes like 15-human lipoxygenase (19952.6 nM), Hydroxyacyl-Coenzyme A Dehydrogenase, Type II (3162.3 nM), and Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) (89125.1 nM). Additionally, it modulates Lamin A splicing with a potency of 251.2 nM and induces DNA re-replication in SW480 colon adenocarcinoma cells at 1835.6 nM. The compound also demonstrates antiviral properties, including blocking the entry of the Ebola Virus (AC50 ranging from 631.0 nM to 1.259 µM) and inhibiting SARS-CoV-2 replication. In terms of pharmacokinetics, it maintains good metabolic stability in human serum and exhibits varying maximum plasma concentrations (Cmax) and times to reach maximum concentration (Tmax) when administered with pseudoephedrine hydrochloride, indicating effective bioavailability and absorption. Fexofenadine hydrochloride has relatively low solubility in water but higher solubility in simulated gastric and intestinal fluids, enhancing its bioavailability under physiological conditions. It shows antifungal activity against Candida albicans and Cryptococcus neoformans and antibacterial activity against multiple strains including Escherichia coli and Klebsiella pneumoniae. Furthermore, the compound affects cell viability across different cell lines and demonstrates both slight destabilization and stabilization of protein domains, indicating its potential for protein interaction modulation. It also exhibits a range of bioactivities in GPCR beta-arrestin recruitment assays, influencing various physiological processes through different receptor pathways. Overall, Fexofenadine hydrochloride is characterized by its diverse bioactivities, stability, and pharmacokinetic properties, making it a compound of interest for further pharmacological and biochemical studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistaminic activity.

Chemical Properties

Molecular Weight	538.12
Formula	C₃₂H₄₀ClNO₄
Cas No.	138452-21-8
Smiles	Cl.O=C(O)C(C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C=3C=CC=CC3)C=4C=CC=CC4)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8583 mL	9.2916 mL	18.5832 mL	92.9161 mL
5 mM	0.3717 mL	1.8583 mL	3.7166 mL	18.5832 mL
10 mM	0.1858 mL	0.9292 mL	1.8583 mL	9.2916 mL
20 mM	0.0929 mL	0.4646 mL	0.9292 mL	4.6458 mL
50 mM	0.0372 mL	0.1858 mL	0.3717 mL	1.8583 mL
100 mM	0.0186 mL	0.0929 mL	0.1858 mL	0.9292 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc