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RF9

Name: RF9
Brand: TargetMol
SKU: T16738
Rating: 4.5 (1 reviews)

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Catalog No. T16738Cas No. 876310-60-0

RF9 is an effective and selective antagonist of the Neuropeptide FF receptor (Kis: 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively).

RF9

😃Good

Catalog No. T16738Cas No. 876310-60-0

RF9 is an effective and selective antagonist of the Neuropeptide FF receptor (Kis: 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$337	35 days	35 days
5 mg	$1,230	35 days	35 days
10 mg	$2,130	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	RF9 is an effective and selective antagonist of the Neuropeptide FF receptor (Kis: 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively).
Targets&IC50	NPFF1R (human):58±5 nM (Ki), NPFF2R (human):75±9 nM(Ki)
In vivo	RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. When NPFF is applied in conjunction with RF9, MAP, and heart rate increases evoked by NPFF are significantly blocked. It is worthy to note that RF9 (30 nmol) significantly reduces the hypothermia induced by morphine (5 nmol) [1][2].

Chemical Properties

Molecular Weight	482.62
Formula	C₂₆H₃₈N₆O₃
Cas No.	876310-60-0
Smiles	NC(=N)NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (310.8 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0720 mL	10.3601 mL	20.7202 mL	103.6012 mL
5 mM	0.4144 mL	2.0720 mL	4.1440 mL	20.7202 mL
10 mM	0.2072 mL	1.0360 mL	2.0720 mL	10.3601 mL
20 mM	0.1036 mL	0.5180 mL	1.0360 mL	5.1801 mL
50 mM	0.0414 mL	0.2072 mL	0.4144 mL	2.0720 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RF-9RF9RF 9hNPFF2RhNPFF1R

RF9

RF9

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