Shopping Cart

Your shopping cart is currently empty

KO-947

Name: KO-947
Brand: TargetMol
SKU: TQ0005
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TQ0005Cas No. 1695533-89-1

KO-947 is a potent and specific ERK1/2 kinase inhibitor.

KO-947

🥰Excellent

Purity: 97.84%

Catalog No. TQ0005Cas No. 1695533-89-1

KO-947 is a potent and specific ERK1/2 kinase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$105	In Stock	In Stock
10 mg	$168	In Stock	In Stock
25 mg	$342	In Stock	In Stock
50 mg	$548	-	In Stock
100 mg	$849	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.84%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KO-947 is a potent and specific ERK1/2 kinase inhibitor.
In vitro	KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling, including mutations in KRAS, NRAS or BRAF, at low nanomolar concentrations.

Chemical Properties

Molecular Weight	355.39
Formula	C₂₁H₁₇N₅O
Cas No.	1695533-89-1
Smiles	O=C1Nc2cc3[nH]nc(-c4ccncc4)c3cc2CN1Cc1ccccc1
Relative Density.	1.354 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (168.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8138 mL	14.0691 mL	28.1381 mL	140.6905 mL
5 mM	0.5628 mL	2.8138 mL	5.6276 mL	28.1381 mL
10 mM	0.2814 mL	1.4069 mL	2.8138 mL	14.0691 mL
20 mM	0.1407 mL	0.7035 mL	1.4069 mL	7.0345 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL	2.8138 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4069 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc