Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

Orilanolimab

Name: Orilanolimab
Brand: TargetMol
SKU: T78325
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T78325Cas No. 2066544-85-0

Alias SYNT001

Orilanolimab (SYNT001) is a humanized, de-immunized monoclonal antibody that inhibits the FcRn-IgG interaction, disrupting IgG homeostasis and impeding FcRn-mediated adaptive immune responses and related innate and adaptive immunity pathways [1] [2].

Orilanolimab

😃Good

Catalog No. T78325Alias SYNT001Cas No. 2066544-85-0

Pack Size	Price	Availability
1 mg	$456	2-4 weeks
5 mg	$1,180	2-4 weeks
10 mg	$1,900	2-4 weeks

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Instruction Manual of Inhibitory Antibody

Product Introduction

Bioactivity

Description	Orilanolimab (SYNT001) is a humanized, de-immunized monoclonal antibody that inhibits the FcRn-IgG interaction, disrupting IgG homeostasis and impeding FcRn-mediated adaptive immune responses and related innate and adaptive immunity pathways [1] [2].
In vitro	Orilanolimab at concentrations of 10nM, 50nM, and 100nM administered over 48 hours, inhibits the production of CD11c⁺ IFN-γ in B2M TG/TG FCGRT TG/TG Fcgrt -/- mice [1].
In vivo	Orilanolimab (20mg/kg; intravenous injection) significantly reduced plasma concentrations of HuLys11 in a murine model [1]. Dose-dependent and specific reductions in the circulating levels of IgG in cynomolgus monkeys were observed following orilanolimab administration (10-100 mg/kg; intravenous injection; every 5 weeks) [1].
Synonyms	SYNT001

Chemical Properties

Cas No.

2066544-85-0

Storage & Solubility Information

Storage

-20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SYNT-001SYNT 001Orilanolimab