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Orilanolimab
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Catalog No. T78325Cas No. 2066544-85-0
Alias SYNT001, SYNT 001, ALXN1830, ALXN 1830
Orilanolimab (SYNT 001, ALXN 1830) is a humanised and deimmunised monoclonal antibody targeting FcRn, disrupting the interaction between FcRn and IgG, and may be used in immunology research.
Orilanolimab
Orilanolimab
😃Good
Purity: 95%
Catalog No. T78325Alias SYNT001, SYNT 001, ALXN1830, ALXN 1830Cas No. 2066544-85-0
Orilanolimab (SYNT 001, ALXN 1830) is a humanised and deimmunised monoclonal antibody targeting FcRn, disrupting the interaction between FcRn and IgG, and may be used in immunology research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $455 | - | In Stock | |
| 5 mg | $1,180 | - | In Stock | |
| 10 mg | $1,890 | - | In Stock | |
| 25 mg | $2,820 | - | In Stock | |
| 50 mg | $3,780 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.3% (SDS-PAGE); 97.0% (SEC-HPLC)
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| Description | Orilanolimab (SYNT 001, ALXN 1830) is a humanised and deimmunised monoclonal antibody targeting FcRn, disrupting the interaction between FcRn and IgG, and may be used in immunology research. |
| In vitro | In primary CD11c+ APCs derived from B2MTG/TGFCGRTTG/TG Fcgrt-/- mice, Orilanolimab (10nM, 50nM, and 100nM，48 hours) suppressed IFN-γ secretion by OVA-specific CD8+ and CD4+ T cells [1]. |
| In vivo | In hFcRn-expressing mouse models, Orilanolimab (20 mg/kg, intravenous injection) significantly reduced the levels of human IgG and IgG ICs in plasma [1]. Orilanolimab (10, 30, 100 mg/kg, intravenous injection, once weekly) induced a dose-dependent and proposed reduction in total circulating IgG levels in cynomolgus monkeys [1]. |
| Synonyms | SYNT001, SYNT 001, ALXN1830, ALXN 1830 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | FcRn (FCGRT & B2M) |
| Molecular Weight | 144.02 kDa |
| Cas No. | 2066544-85-0 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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