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TC-MCH 7c

Name: TC-MCH 7c
Brand: TargetMol
SKU: T13101
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13101 Copy Product Info

Purity: 99.54%

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TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.

Cas No. 864756-35-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$95	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$415	In Stock	In Stock
25 mg	$636	In Stock	In Stock
50 mg	$858	In Stock	In Stock
100 mg	$1,150	In Stock	In Stock
500 mg	$2,310	-	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.54%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
Targets & IC50	MCH1R (mouse):3.0 nM , MCH1R (human):3.4 nM (ki), MCH1R (human):(ki)3.4 nM , MCH1R (human):5.6 nM, MCH1R (human):5.6 nM , MCH1R (mouse):3.0 nM
In vitro	In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2].
In vivo	In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2].

Chemical Properties

Molecular Weight	408.47
Formula	C₂₄H₂₅FN₂O₃
Cas No.	864756-35-4
Smiles	Fc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (153.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 6.25 mg/mL (15.3 mM), Solution.

10% DMSO+90% Saline: < 6.25 mg/mL (15.3 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4482 mL	12.2408 mL	24.4816 mL	122.4080 mL
5 mM	0.4896 mL	2.4482 mL	4.8963 mL	24.4816 mL
10 mM	0.2448 mL	1.2241 mL	2.4482 mL	12.2408 mL
20 mM	0.1224 mL	0.6120 mL	1.2241 mL	6.1204 mL
50 mM	0.0490 mL	0.2448 mL	0.4896 mL	2.4482 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2241 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc