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Holomycin
(Synonyms: N-Demethylthiolutin) Copy Product Info
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Synonyms: N-Demethylthiolutin
Catalog No. T67731 Copy Product Info
Purity: 98.76%
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Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753 and is also a broad-spectrum antibiotic. holomycin promotes biofilm formation of S2753 through its alene-disthionyl group. Holomycin has antitumor activity and is involved in RNA synthesis.
Cas No. 488-04-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $298 | In Stock | In Stock | |
| 5 mg | $678 | In Stock | In Stock | |
| 10 mg | $912 | In Stock | In Stock | |
| 25 mg | $1,350 | In Stock | In Stock | |
| 50 mg | $1,780 | In Stock | In Stock | |
| 100 mg | $2,380 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $597 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:98.76%
Appearance:Solid
Color:Orange
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Product Introduction
Holomycin AI Summary
Holomycin exhibits antimicrobial activity against Staphylococcus epidermidis, with a Minimum Inhibitory Concentration (MIC) of 12.5 µg/mL and a Minimum Bactericidal Concentration (MBC) of 50.0 µg/mL, resulting in an MBC to MIC ratio of 4.0. Furthermore, it inhibits Staphylococcus epidermidis RNA polymerase-mediated transcription, with an IC50 value greater than 100.0 µg/mL..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753 and is also a broad-spectrum antibiotic. holomycin promotes biofilm formation of S2753 through its alene-disthionyl group. Holomycin has antitumor activity and is involved in RNA synthesis. |
| Synonyms | N-Demethylthiolutin |
| Molecular Weight | 214.26 |
| Formula | C7H6N2O2S2 |
| Cas No. | 488-04-0 |
| Smiles | CC(=O)Nc1c2sscc2[nH]c1=O |
| Relative Density. | 1.63 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 77.5 mg/mL (361.71 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 7.75 mg/mL (36.17 mM), Solution. 10% DMSO+90% Saline: < 7.75 mg/mL (36.17 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Holomycin chemical structure | Holomycin formula | Holomycin molecular weight
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