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MOG peptide (35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and induces experimental autoimmune encephalomyelitis (EAE) in animal models [1] [2] [3].

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $76 | 7-10 days | 7-10 days | |
| 5 mg | $178 | 7-10 days | 7-10 days | |
| 10 mg | $278 | 7-10 days | 7-10 days | |
| 25 mg | $518 | 7-10 days | 7-10 days | |
| 50 mg | $798 | 7-10 days | 7-10 days |
| Description | MOG peptide (35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and induces experimental autoimmune encephalomyelitis (EAE) in animal models [1] [2] [3]. |
| In vitro | The expanded CD4+ T cells predominantly target the immunogenic peptide 35-55 of myelin oligodendrocyte glycoprotein (MOG35-55). In contrast, clonally expanded CD8+ T cells exhibit no response to myelin-derived peptides or proteins [1]. |
| In vivo | Administration of MOG peptide (35-55) at a concentration of 3 mg/mL (0.1 mL, s.c., single dose) actively induces experimental autoimmune encephalomyelitis (EAE) in mice [2]. Additionally, a single subcutaneous dose of MOG peptide (35-55) at 200 μg results in an increased level of the eosinophil chemoattractant eotaxin-1 in the spinal cord during EAE progression in C57BL/6 mice [3]. |
| Molecular Weight | 2580.97 |
| Formula | C118H178N36O28S |
| Cas No. | 2022956-48-3 |
| Smiles | C([C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N)=O)=O)=O)CC(N)=O)=O)CCCNC(=N)N)=O)=O)CC(C)C)=O)=O)[C@H](C)C)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)CO)=O)=O)CCC2)CO)=O)CCCNC(=N)N)=O)=O)NC(CNC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)C(C)C)=O)=O)C=6C=7C(NC6)=CC=CC7 |
| Sequence | Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-NH2 |
| Sequence Short | MEVGWYRSPFSRVVHLYRNGK |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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