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MOG peptide (35-55) amide
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Catalog No. T78031Cas No. 2022956-48-3
MOG peptide (35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and induces experimental autoimmune encephalomyelitis (EAE) in animal models [1] [2] [3].
MOG peptide (35-55) amide
😃Good
Catalog No. T78031Cas No. 2022956-48-3
MOG peptide (35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and induces experimental autoimmune encephalomyelitis (EAE) in animal models [1] [2] [3].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $76 | 7-10 days | 7-10 days | |
| 5 mg | $178 | 7-10 days | 7-10 days | |
| 10 mg | $278 | 7-10 days | 7-10 days | |
| 25 mg | $518 | 7-10 days | 7-10 days | |
| 50 mg | $798 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | MOG peptide (35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and induces experimental autoimmune encephalomyelitis (EAE) in animal models [1] [2] [3]. |
| In vitro | The expanded CD4+ T cells predominantly target the immunogenic peptide 35-55 of myelin oligodendrocyte glycoprotein (MOG35-55). In contrast, clonally expanded CD8+ T cells exhibit no response to myelin-derived peptides or proteins [1]. |
| In vivo | Administration of MOG peptide (35-55) at a concentration of 3 mg/mL (0.1 mL, s.c., single dose) actively induces experimental autoimmune encephalomyelitis (EAE) in mice [2]. Additionally, a single subcutaneous dose of MOG peptide (35-55) at 200 μg results in an increased level of the eosinophil chemoattractant eotaxin-1 in the spinal cord during EAE progression in C57BL/6 mice [3]. |
| Molecular Weight | 2580.97 |
| Formula | C118H178N36O28S |
| Cas No. | 2022956-48-3 |
| Smiles | C([C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N)=O)=O)=O)CC(N)=O)=O)CCCNC(=N)N)=O)=O)CC(C)C)=O)=O)[C@H](C)C)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)CO)=O)=O)CCC2)CO)=O)CCCNC(=N)N)=O)=O)NC(CNC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)C(C)C)=O)=O)C=6C=7C(NC6)=CC=CC7 |
| Sequence | Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-NH2 |
| Sequence Short | MEVGWYRSPFSRVVHLYRNGK-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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