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C6 Ceramide

Name: C6 Ceramide
Brand: TargetMol
SKU: T61884
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61884Cas No. 124753-97-5

Alias N-hexanoylsphingosine, N-(hexanoyl)sphing-4-enine

C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines.

C6 Ceramide

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Purity: 99.73%

Catalog No. T61884Alias N-hexanoylsphingosine, N-(hexanoyl)sphing-4-enineCas No. 124753-97-5

C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$189	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$488	-	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

C6 Ceramide AI Summary

C6 Ceramide exhibits cytotoxicity against various human cancer cell lines: A549 cells (IC50 = 35000.0 nM after 72 hours, MTT test), SupT1 cells (IC50 = 48010.0 nM after 24 hours, CellTiter-Blue assay), and MCF7 cells (IC50 = 12000.0 nM after 24 hours, demonstrating antiproliferative activity). In MCF7 cells, it also demonstrates metabolic stability with significant modulation of ceramide and sphingolipid levels, exhibiting fold changes from 0.2 to 80.0 for different species. C6 Ceramide is a bioactive inhibitor in several assays: Inhibits the thyroid hormone receptor and steroid receptor coregulator 2 interaction (potency = 354813.4 nM), polymerase kappa (potency = 2667.9 nM), Marburg virus binding/entry (potency = 5011.9 nM), and human apurinic/apyrimidinic endonuclease 1 (APE1) (potency = 31622.8 nM). Additionally, it inhibits electric eel acetylcholinesterase (9.07%) and horse butyrylcholinesterase (4.36%) at a concentration of 2 mg/ml..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines.
Synonyms	N-hexanoylsphingosine, N-(hexanoyl)sphing-4-enine

Chemical Properties

Molecular Weight	397.63
Formula	C₂₄H₄₇NO₃
Cas No.	124753-97-5
Smiles	CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (226.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5149 mL	12.5745 mL	25.1490 mL	125.7450 mL
5 mM	0.5030 mL	2.5149 mL	5.0298 mL	25.1490 mL
10 mM	0.2515 mL	1.2575 mL	2.5149 mL	12.5745 mL
20 mM	0.1257 mL	0.6287 mL	1.2575 mL	6.2873 mL
50 mM	0.0503 mL	0.2515 mL	0.5030 mL	2.5149 mL
100 mM	0.0251 mL	0.1257 mL	0.2515 mL	1.2575 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc