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TAS-114

🥰Excellent
Catalog No. T13089Cas No. 1198221-21-4
Alias TAS114, TAS 114

TAS-114 is an orally active dual inhibitor of dUTPase and dihydropyrimidine dehydrogenase (DPD). TAS-114 targets the intercellular metabolism of 5-FU to enhance antitumor activity and modulates catabolic pathways to improve the systemic availability of 5-FU.

TAS-114

TAS-114

🥰Excellent
Purity: 99.76%
Catalog No. T13089Alias TAS114, TAS 114Cas No. 1198221-21-4
TAS-114 is an orally active dual inhibitor of dUTPase and dihydropyrimidine dehydrogenase (DPD). TAS-114 targets the intercellular metabolism of 5-FU to enhance antitumor activity and modulates catabolic pathways to improve the systemic availability of 5-FU.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$299-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.76%
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Product Introduction

Bioactivity
Description
TAS-114 is an orally active dual inhibitor of dUTPase and dihydropyrimidine dehydrogenase (DPD). TAS-114 targets the intercellular metabolism of 5-FU to enhance antitumor activity and modulates catabolic pathways to improve the systemic availability of 5-FU.
In vitro
In HeLa, NUGC-4, NCI-H441, HT-29, CFPAC-1, and MCF-7 cell lines, TAS-114 (72 hours; 1 μM, 3 μM, and 10 μM) can significantly enhance the cytotoxicity of FdUrd and 5-FU against various cancer cell lines in a dose-dependent manner[1].
In vivo
In BALB/c nude mice with MX-1 human breast cancer xenografts, TAS-114 (37.5 to 1200 mg/kg/day; orally; daily; 1-14 days) can decrease the tolerable doses of Capecitabine (539 mg/kg/day) in a dose-dependent manner in mice[1].
SynonymsTAS114, TAS 114
Chemical Properties
Molecular Weight451.54
FormulaC21H29N3O6S
Cas No.1198221-21-4
SmilesC[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OC2CCCC2)c1
Relative Density.1.290 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (177.17 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.31 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2146 mL11.0732 mL22.1464 mL110.7322 mL
5 mM0.4429 mL2.2146 mL4.4293 mL22.1464 mL
10 mM0.2215 mL1.1073 mL2.2146 mL11.0732 mL
20 mM0.1107 mL0.5537 mL1.1073 mL5.5366 mL
50 mM0.0443 mL0.2215 mL0.4429 mL2.2146 mL
100 mM0.0221 mL0.1107 mL0.2215 mL1.1073 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAS-114dUTPase, DPDdihydropyrimidine dehydrogenase (DPD)
Related Tags: buy TAS-114 | purchase TAS-114 | TAS-114 cost | order TAS-114 | TAS-114 chemical structure | TAS-114 in vivo | TAS-114 in vitro | TAS-114 formula | TAS-114 molecular weight
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