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7-Oxogedunin

Catalog No. TN13531 Copy Product Info
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7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from pyroptosis induced by anthrax lethal toxin (LT) by targeting protein kinase R (PKR). By inhibiting the kinase-independent functions of PKR, 7-Oxogedunin effectively suppresses the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1. It also exhibits growth inhibitory activity against European corn borer larvae. 7-Oxogedunin is used in research focusing on LT toxicity inhibition and insecticidal studies.

7-Oxogedunin

Copy Product Info
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Catalog No. TN13531

7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from pyroptosis induced by anthrax lethal toxin (LT) by targeting protein kinase R (PKR). By inhibiting the kinase-independent functions of PKR, 7-Oxogedunin effectively suppresses the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1. It also exhibits growth inhibitory activity against European corn borer larvae. 7-Oxogedunin is used in research focusing on LT toxicity inhibition and insecticidal studies.

7-Oxogedunin
Cas No. 13072-74-7
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from pyroptosis induced by anthrax lethal toxin (LT) by targeting protein kinase R (PKR). By inhibiting the kinase-independent functions of PKR, 7-Oxogedunin effectively suppresses the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1. It also exhibits growth inhibitory activity against European corn borer larvae. 7-Oxogedunin is used in research focusing on LT toxicity inhibition and insecticidal studies.
Chemical Properties
Molecular Weight438.52
FormulaC26H30O6
Cas No.13072-74-7
SmilesC[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]6(C)[C@@](CC2=O)(C(C)(C)C(=O)C=C6)[H])[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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