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Synonyms: PTA, FXI, F11, Coagulation factor XI


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $123 | 7-10 days | 7-10 days | |
| 20 µg | $193 | 7-10 days | 7-10 days | |
| 50 µg | $348 | 7-10 days | 7-10 days | |
| 100 µg | $553 | 7-10 days | 7-10 days | |
| 200 µg | $878 | 7-10 days | 7-10 days | |
| 500 µg | $1,630 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Rabbit Coagulation factor XI, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-factor XI Antibody, hFc Tag with the EC50 of 4.5 ng/ml determined by ELISA (QC Test). |
| Description | Coagulation factor XI/F11 Protein, Rabbit, Recombinant (His) is expressed in HEK293 Cells. The accession number is G1SSQ6. |
| Species | Rabbit |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | G1SSQ6 |
| Construction | Glu19-Pro624 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in PBS (pH 7.4). |
| Synonyms | PTA, FXI, F11, Coagulation factor XI |
| Research Background | Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII.In contrast to its mild hemostatic activities, FXI is known to play a significant role in thrombosis, as it is a demonstrated independent risk factor for deep vein thrombosis, ischemic stroke, and myocardial infarction. A better understanding of the varied and complex role of FXI in both thrombosis and hemostasis will help to allow better prediction of bleeding risk in FXI-deficient patients and also informing the development of targeted agents to inhibit the thrombotic activities of FXI while preserving hemostasis. |
| Molecular Weight | 69.61 kDa (Predicted); 70-90 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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