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Eltanexor

Name: Eltanexor
Brand: TargetMol
SKU: T11766L
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11766LCas No. 1642300-52-4

Alias ONO-7706, KPT-8602, ATG-016

Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.

Eltanexor

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Purity: 99.72%

Catalog No. T11766LAlias ONO-7706, KPT-8602, ATG-016Cas No. 1642300-52-4

Pack Size	Price	Availability
1 mg	$60	In Stock
2 mg	$108	In Stock
5 mg	$237	In Stock
10 mg	$282	In Stock
25 mg	$466	In Stock
50 mg	$662	In Stock
100 mg	$959	In Stock
500 mg	$1,920	In Stock
1 mL x 10 mM (in DMSO)	$223	In Stock

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Batch Information

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Purity:99.72%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.
Targets&IC50	XPO1:60.9 nM(EC50)
In vitro	Eltanexor (KPT-8602) (1 nM; 16 hours) causes apoptosis in leukemia cell lines. KPT-8602 (2-6 nM; 72 hours) decreases cell viability in leukemia cell lines (EC50s ranging from 25 to 145 nM).
In vivo	KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) demonstrates potent anti-lymphoblastic leukemia activity.
Synonyms	ONO-7706, KPT-8602, ATG-016

Chemical Properties

Molecular Weight	428.29
Formula	C₁₇H₁₀F₆N₆O
Cas No.	1642300-52-4
Smiles	NC(=O)C(=C\n1cnc(n1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)\c1cncnc1
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (186.79 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3349 mL	11.6743 mL	23.3487 mL	116.7433 mL
5 mM	0.4670 mL	2.3349 mL	4.6697 mL	23.3487 mL
10 mM	0.2335 mL	1.1674 mL	2.3349 mL	11.6743 mL
20 mM	0.1167 mL	0.5837 mL	1.1674 mL	5.8372 mL
50 mM	0.0467 mL	0.2335 mL	0.4670 mL	2.3349 mL
100 mM	0.0233 mL	0.1167 mL	0.2335 mL	1.1674 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc