Glycol chitosan

Name: Glycol chitosan
Brand: TargetMol
SKU: T13708
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13708Cas No. 123938-86-3

Glycol chitosan, a chitosan derivative with hydrophilic ethylene glycol branches, inhibits E. coli, S. aureus, and S. enteritidis growth (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL), and enhances membrane permeability and leakage in Glycine max [Harosoy 63W] cells.

Glycol chitosan

🥰Excellent

Catalog No. T13708Cas No. 123938-86-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$40	In Stock	In Stock

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Appearance:Solid

Color:White to Yellow

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Product Introduction

Bioactivity

Description	Glycol chitosan, a chitosan derivative with hydrophilic ethylene glycol branches, inhibits E. coli, S. aureus, and S. enteritidis growth (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL), and enhances membrane permeability and leakage in Glycine max [Harosoy 63W] cells.
Targets&IC50	S. aureus: 32 μg/mL , E. coli:(MIC)4 μg/mL , S. enteritidis:<0.5 μg/mL
In vitro	The hydrophobic modification of Glycol chitosan has been validated, with derivatives such as Glycol chitosan with a 5β-cholanic acid moiety and deoxycholic acid-Glycol chitosan, capable of self-assembling into nanoparticles, demonstrating potential as carriers for hydrophobic drugs and genes [2]. Glycol chitosan can be covalently bonded with hydrophobic drugs to create amphiphilic compounds that form nanoparticles (NPs) useful in cell imaging and drug delivery. These derivatives are effectively utilized to transport antimicrobial and anticancer agents, employing either physical encapsulation or chemical conjugation methods. Glycol chitosan derivatives are advantageous for cell imaging and drug delivery due to their exceptional tumor-targeting capabilities stemming from the enhanced permeability and retention (EPR) effect, minimal cytotoxicity, chemical modifiability, high biocompatibility, and degradability [1].

Chemical Properties

Cas No.	123938-86-3
Smiles	N.N[C@H]1[C@H](O)O[C@H](COCCO)[C@@H](O[C@@H]2O[C@H](COCCO)[C@@H](O[C@@H]3O[C@H](COCCO)[C@@H](O)[C@H](O)[C@H]3N)[C@H](O)[C@H]2N)[C@@H]1O
Relative Density.	no data available

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	H2O: 7.50 mg/mL, Sonication is recommended. DMSO: 11.67 mg/mL, Sonication is recommended.
In Vivo Formulation	10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL, Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc