Shopping Cart
Remove All
Your shopping cart is currently empty
D1/D5 Receptor agonist-1
😃Good
Catalog No. T212004
D1/D5 Receptor agonist-1 is an orally active D1/D5 receptor agonist with the ability to cross the blood-brain barrier. It demonstrates significant efficacy in the cAMP pathway and β-arrestin recruitment, with EC50 values of 3.7 nM for D1R cAMP, 91 nM for D1R β-arrestin, and 129 nM for D1R internalization, and a Ki value of 111 nM for D1R binding affinity. In rats, D1/D5 Receptor agonist-1 inhibits β-arrestin signaling involved in L-DOPA-induced dyskinesia. This compound is applicable in Parkinson's disease research.
D1/D5 Receptor agonist-1
D1/D5 Receptor agonist-1
😃Good
Catalog No. T212004
D1/D5 Receptor agonist-1 is an orally active D1/D5 receptor agonist with the ability to cross the blood-brain barrier. It demonstrates significant efficacy in the cAMP pathway and β-arrestin recruitment, with EC50 values of 3.7 nM for D1R cAMP, 91 nM for D1R β-arrestin, and 129 nM for D1R internalization, and a Ki value of 111 nM for D1R binding affinity. In rats, D1/D5 Receptor agonist-1 inhibits β-arrestin signaling involved in L-DOPA-induced dyskinesia. This compound is applicable in Parkinson's disease research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | D1/D5 Receptor agonist-1 is an orally active D1/D5 receptor agonist with the ability to cross the blood-brain barrier. It demonstrates significant efficacy in the cAMP pathway and β-arrestin recruitment, with EC50 values of 3.7 nM for D1R cAMP, 91 nM for D1R β-arrestin, and 129 nM for D1R internalization, and a Ki value of 111 nM for D1R binding affinity. In rats, D1/D5 Receptor agonist-1 inhibits β-arrestin signaling involved in L-DOPA-induced dyskinesia. This compound is applicable in Parkinson's disease research. |
| In vitro | D1/D5 Receptor agonist-1 (Compound 24) (10⁻⁴ - 10 μM) demonstrates significant efficacy in the cAMP pathway and β-arrestin protein recruitment, with EC₅₀ values of 3.7 nM for D1R cAMP, 91 nM for D1R β-arrestin, and 129 nM for D1R internalization. The compound shows a binding affinity Kᵢ value of 111 nM for D1R. |
| In vivo | Compound 24, a D1/D5 receptor agonist, administered orally in a single dose of 0.3-3 mg/kg, inhibits β-arrestin signaling in a rat model of L-DOPA-induced dyskinesia in Parkinson's disease. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy D1/D5 Receptor agonist-1 | purchase D1/D5 Receptor agonist-1 | D1/D5 Receptor agonist-1 cost | order D1/D5 Receptor agonist-1 | D1/D5 Receptor agonist-1 in vivo | D1/D5 Receptor agonist-1 in vitro
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.