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Anti-epithelial Sodium Channel gamma Polyclonal Antibody
Catalog No. TMAB-05631 Copy Product Info
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Anti-epithelial Sodium Channel gamma Polyclonal Antibody is a Rabbit antibody targeting epithelial Sodium Channel gamma. Anti-epithelial Sodium Channel gamma Polyclonal Antibody can be used in WB.
Anti-epithelial Sodium Channel gamma Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-05631
Anti-epithelial Sodium Channel gamma Polyclonal Antibody is a Rabbit antibody targeting epithelial Sodium Channel gamma. Anti-epithelial Sodium Channel gamma Polyclonal Antibody can be used in WB.
Anti-epithelial Sodium Channel gamma Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Antigen Details
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| Description | Anti-epithelial Sodium Channel gamma Polyclonal Antibody is a Rabbit antibody targeting epithelial Sodium Channel gamma. Anti-epithelial Sodium Channel gamma Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Rabbit) |
| Verified Activity | Sample: Lung (Mouse) Lysate at 40 μg Primary: Anti-epithelial Sodium Channel gamma (TMAB-05631) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 71 kD Observed band size: 71/81 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1). |
| Immunogen | KLH conjugated synthetic peptide: human epithelial Sodium Channel gamma |
| Antigen Species | Human |
| Gene Name | SCNN1G |
| Gene ID | |
| Protein Name | Epithelial sodium channel subunit gamma |
| Uniprot ID | |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Molecular Weight | Theoretical: 71 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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