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PLH1215

Name: PLH1215
Brand: TargetMol
SKU: T77335
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77335Cas No. 1332084-64-6

PLH1215 is an effective AHR inhibitor that can be used to modulate, limit, or suppress the expression of AVIL (advillin). PLH1215 can be employed for the prevention and treatment of cancer.

PLH1215

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Purity: 99.98%

Catalog No. T77335Cas No. 1332084-64-6

PLH1215 is an effective AHR inhibitor that can be used to modulate, limit, or suppress the expression of AVIL (advillin). PLH1215 can be employed for the prevention and treatment of cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	In Stock	In Stock
5 mg	$132	In Stock	In Stock
10 mg	$190	In Stock	In Stock
25 mg	$320	In Stock	In Stock
50 mg	$480	In Stock	In Stock
100 mg	$687	In Stock	In Stock
500 mg	$1,480	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PLH1215 is an effective AHR inhibitor that can be used to modulate, limit, or suppress the expression of AVIL (advillin). PLH1215 can be employed for the prevention and treatment of cancer.
In vitro	METHODS: U87 cells and astrocytes were treated with PLH1215 (0-80 µM) for 3 days and cell viability was determined by MTT assay. RESULTS: The majority of U87 cells were eliminated with the compound PLH1252 at less than 1 mM, while no significant effect was seen in astrocytes. [1]

Chemical Properties

Molecular Weight	326.44
Formula	C₁₉H₂₆N₄O
Cas No.	1332084-64-6
Smiles	C(CCC1=CC=CC=C1)C2(CO)CN(CCC2)C3=NC(N)=NC=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (153.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0634 mL	15.3168 mL	30.6335 mL	153.1675 mL
5 mM	0.6127 mL	3.0634 mL	6.1267 mL	30.6335 mL
10 mM	0.3063 mL	1.5317 mL	3.0634 mL	15.3168 mL
20 mM	0.1532 mL	0.7658 mL	1.5317 mL	7.6584 mL
50 mM	0.0613 mL	0.3063 mL	0.6127 mL	3.0634 mL
100 mM	0.0306 mL	0.1532 mL	0.3063 mL	1.5317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc