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USP7-IN-1

Name: USP7-IN-1
Brand: TargetMol
SKU: T13268
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13268Cas No. 1381291-36-6

USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 77 μM.

USP7-IN-1

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Purity: 99.82%

Catalog No. T13268Cas No. 1381291-36-6

USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 77 μM.

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$198	In Stock
10 mg	$298	In Stock
25 mg	$476	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
200 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$229	In Stock

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Purity:99.82%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 77 μM.
Targets&IC50	USP7:77 μM
In vitro	USP7-IN-1 is a selective and reversible USP7 inhibitor(IC50 of 77 μM). USP7-IN-1 inhibits the proliferation of HCT116 cells(GI50 of 67 μM).

Chemical Properties

Molecular Weight	425.91
Formula	C₂₃H₂₄ClN₃O₃
Cas No.	1381291-36-6
Smiles	OC1(Cn2cnc3cc(Cl)ccc3c2=O)CCN(CC1)C(=O)CCc1ccccc1
Relative Density.	1.32 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (129.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3479 mL	11.7396 mL	23.4791 mL	117.3957 mL
5 mM	0.4696 mL	2.3479 mL	4.6958 mL	23.4791 mL
10 mM	0.2348 mL	1.1740 mL	2.3479 mL	11.7396 mL
20 mM	0.1174 mL	0.5870 mL	1.1740 mL	5.8698 mL
50 mM	0.0470 mL	0.2348 mL	0.4696 mL	2.3479 mL
100 mM	0.0235 mL	0.1174 mL	0.2348 mL	1.1740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc