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Fasitibant chloride
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Catalog No. T38544Cas No. 1157852-02-2
Alias MEN16132 free base, Fasitibant chloride
Fasitibant chloride (MEN16132 free base) is a potent and specific nonpeptide antagonist of the bradykinin B2 receptor (B2R), effectively reducing joint pain and mitigating joint edema in a rat model of Carrageenan-induced arthritis.
Fasitibant chloride
Copy Product Info😃Good
Catalog No. T38544Alias MEN16132 free base, Fasitibant chlorideCas No. 1157852-02-2
Fasitibant chloride (MEN16132 free base) is a potent and specific nonpeptide antagonist of the bradykinin B2 receptor (B2R), effectively reducing joint pain and mitigating joint edema in a rat model of Carrageenan-induced arthritis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Fasitibant chloride (MEN16132 free base) is a potent and specific nonpeptide antagonist of the bradykinin B2 receptor (B2R), effectively reducing joint pain and mitigating joint edema in a rat model of Carrageenan-induced arthritis. |
| In vitro | Fasitibant chloride (MEN16132 free base; 1 μM; pre-treatment 30 min before BK) consistently reduces FGF-2 expression and diminishes BK-induced FGFR-1 phosphorylation without affecting FGFR-2 activity in HUVECs, also impeding the phosphorylation of FRSα, ERK1/2, and STAT3 but not AKT. In a cell viability assay on HUVECs, it demonstrated the same reduction in FGF-2 expression and decrease in BK-induced FGFR-1 phosphorylation. |
| In vivo | Fasitibant chloride (MEN16132 free base; 100 μg per knee; injected into the knee 30 minutes before λ-carrageenan) effectively reduces carrageenan-induced joint pain and knee joint edema by 40-45% in male Wistar rats weighing 250-300 g[1]. The treatment also significantly decreases neutrophil infiltration in the synovium by approximately 60% and prostaglandin release by around 30%, showcasing potent anti-inflammatory and analgesic properties. |
| Synonyms | MEN16132 free base, Fasitibant chloride |
| Molecular Weight | 800.23 |
| Formula | C36H49Cl3N6O6S |
| Cas No. | 1157852-02-2 |
| Smiles | [Cl-].Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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