Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, respectively [1]. Agomelatine hydrochloride is a selective antagonist of a 5-HT2C receptor with pKis of 6.4 and 6.2 for native (porcine) and cloned, human 5-HT2C receptors, respectively [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 85.00 | |
25 mg | In stock | $ 153.00 | |
50 mg | In stock | $ 257.00 | |
100 mg | In stock | $ 327.00 | |
200 mg | In stock | $ 488.00 | |
500 mg | In stock | $ 783.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 58.00 |
Description | Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, respectively [1]. Agomelatine hydrochloride is a selective antagonist of a 5-HT2C receptor with pKis of 6.4 and 6.2 for native (porcine) and cloned, human 5-HT2C receptors, respectively [2]. |
In vitro | Agomelatine (S 20098) functions as a full agonist for the MT1 and MT2 receptors, exhibiting EC50 values of 1.6±0.4 and 0.10±0.04 nM, respectively, when expressed in CHO or HEK cell membranes. Additionally, Agomelatine interacts with h5-HT2B receptors, displaying a marked preference (6.6). However, it demonstrates low affinity for both native and cloned human 5-HT2A receptors, with values just below 5.0/5.3, and similarly low affinity for 5-HT1A receptors (below 5.0/5.2), while exhibiting negligible affinity for other 5-HT receptors. |
In vivo | Agomelatine (25, 50, or 75 mg/kg; i.p.) has antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice. Agomelatine dose not have any antioxidant effects on parameters of oxidative stress produced by Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models when compared to controls[3]. |
Synonyms | S-20098 hydrochloride |
Molecular Weight | 279.76 |
Formula | C15H18ClNO2 |
CAS No. | 1176316-99-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 0.1 mg/mL (insoluble)
DMSO: 90mg/mL (321.7mM)
You can also refer to dose conversion for different animals. More
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Agomelatine hydrochloride 1176316-99-6 Neuroscience MT Receptor S-20098 Hydrochloride Agomelatine Hydrochloride S 20098 Hydrochloride S20098 Hydrochloride S-20098 hydrochloride inhibitor inhibit