Anti-SMAD1 Polyclonal Antibody

Name: Anti-SMAD1 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01734
Rating: 4.5 (1 reviews)

(Synonyms: Transforming Growth Factor-β-Signaling Protein 1, Transforming Growth Factor-Beta-Signaling Protein 1, SMAD1, SMAD Family Member 1, SMAD 1, Mothers Against DPP Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mad-Related Protein 1, MADR1, MADH1, MAD Homolog 1, JV4-1, hSMAD1, BSP-1, BSP1) Copy Product Info

🥰Excellent

Synonyms: Transforming Growth Factor-β-Signaling Protein 1, Transforming Growth Factor-Beta-Signaling Protein 1, SMAD1, SMAD Family Member 1, SMAD 1, Mothers Against DPP Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mad-Related Protein 1, MADR1, MADH1, MAD Homolog 1, JV4-1, hSMAD1, BSP-1, BSP1

Catalog No. TMAB-01734 Copy Product Info

🥰Excellent

Anti-SMAD1 Polyclonal Antibody is a Rabbit antibody targeting SMAD1. Anti-SMAD1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-SMAD1 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-SMAD1 Polyclonal Antibody is a Rabbit antibody targeting SMAD1. Anti-SMAD1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	Transforming Growth Factor-β-Signaling Protein 1, Transforming Growth Factor-Beta-Signaling Protein 1, SMAD1, SMAD Family Member 1, SMAD 1, Mothers Against DPP Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mad-Related Protein 1, MADR1, MADH1, MAD Homolog 1, JV4-1, hSMAD1, BSP-1, BSP1
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Chicken)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
Tissue Specificity	Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human SMAD1
Antigen Species	Human
Gene Name	SMAD1
Gene ID	4086
Protein Name	Mothers against decapentaplegic homolog 1
Uniprot ID	Q15797
Biology Area	TGF,SMADs,SMADs,Cytoplasmic
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.