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Anti-RON/CD136 Antibody (6E812)
😃Good
Catalog No. TMAY-01924
Alias RON, PTK8, macrophage stimulating 1 receptor, CDw136, CD136
Anti-RON/CD136 Antibody (6E812) is a Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody (6E812) can be used in ELISA.
Anti-RON/CD136 Antibody (6E812)
Anti-RON/CD136 Antibody (6E812)
😃Good
Catalog No. TMAY-01924Alias RON, PTK8, macrophage stimulating 1 receptor, CDw136, CD136
Anti-RON/CD136 Antibody (6E812) is a Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody (6E812) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-RON/CD136 Antibody (6E812) is a Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody (6E812) can be used in ELISA. |
| Alias | RON, PTK8, macrophage stimulating 1 receptor, CDw136, CD136 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6E812 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD136 / MST1R (rh CD136 / MST1R; TMPY-02028; Q04912; Met 1-Leu 571). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphatidylinositol (PI)3-kinase pathway, and the JNK pathway. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD136 / MST1R protein (TMPY-02028) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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