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Bis(maltolato)oxovanadium(IV)

Name: Bis(maltolato)oxovanadium(IV)
Brand: TargetMol
SKU: T22276
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22276Cas No. 38213-69-3

Alias BMOV, Bis(maltolato)oxovanadium (IV), Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive, and orally active pan-PTP (protein tyrosine phosphatases) inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitizer and has been shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ, and SHP2 with IC50s of 126 nM, 109 nM, 26 nM, and 201 nM, respectively [1][2].

Bis(maltolato)oxovanadium(IV)

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Purity: 99.91%

Catalog No. T22276Alias BMOV, Bis(maltolato)oxovanadium (IV), Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadiumCas No. 38213-69-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	-	In Stock
10 mg	$59	-	In Stock
25 mg	$122	-	In Stock
50 mg	$197	-	In Stock
100 mg	$313	-	In Stock
200 mg	$468	-	In Stock
500 mg	$753	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.91%

Appearance:Solid

Color:Black

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COA LCMS

Product Introduction

Bioactivity

Description	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive, and orally active pan-PTP (protein tyrosine phosphatases) inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitizer and has been shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ, and SHP2 with IC50s of 126 nM, 109 nM, 26 nM, and 201 nM, respectively [1][2].
Targets&IC50	HCPTPA:126 nM (IC50), PTP1B:109 nM (IC50), HPTPβ:26 nM (IC50), SHP2:201 nM (IC50)
In vitro	BMOV treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. BMOV treatment also resultes in an increased glucose uptake in C2C12 cells[1].
In vivo	BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
Animal Research	BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
Synonyms	BMOV, Bis(maltolato)oxovanadium (IV), Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium

Chemical Properties

Molecular Weight	317.15
Formula	C₁₂H₁₀O₇V
Cas No.	38213-69-3
Smiles	O=[V+2]12([O-]C=3C(=O1)C=COC3C)[O-]C=4C(=O2)C=COC4C
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13 mg/mL (40.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1531 mL	15.7654 mL	31.5308 mL	157.6541 mL
5 mM	0.6306 mL	3.1531 mL	6.3062 mL	31.5308 mL
10 mM	0.3153 mL	1.5765 mL	3.1531 mL	15.7654 mL
20 mM	0.1577 mL	0.7883 mL	1.5765 mL	7.8827 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc