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MYCi975 (Alias: NUCC-0200975)

Name: MYCi975
Brand: TargetMol
SKU: T12133
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12133 Copy Product Info

Purity: 99.82%

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MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.

MYCi975

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Catalog No. T12133

Alias NUCC-0200975

MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.

Cas No. 2289691-01-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$127	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$492	In Stock	In Stock
25 mg	$819	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$383	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.82%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.
In vitro	MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1].
In vivo	The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.
Synonyms	NUCC-0200975

Chemical Properties

Molecular Weight	561.3
Formula	C₂₅H₁₆Cl₂F₆N₂O₂
Cas No.	2289691-01-4
Smiles	O(CC1=CC=C(Cl)C=C1)C2=C(C(O)=C(C=C2)C3=CC(C(F)(F)F)=NN3C)C4=CC(C(F)(F)F)=C(Cl)C=C4
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (440.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7816 mL	8.9079 mL	17.8158 mL	89.0789 mL
5 mM	0.3563 mL	1.7816 mL	3.5632 mL	17.8158 mL
10 mM	0.1782 mL	0.8908 mL	1.7816 mL	8.9079 mL
20 mM	0.0891 mL	0.4454 mL	0.8908 mL	4.4539 mL
50 mM	0.0356 mL	0.1782 mL	0.3563 mL	1.7816 mL
100 mM	0.0178 mL	0.0891 mL	0.1782 mL	0.8908 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc