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MYCi975

Name: MYCi975
Brand: TargetMol
SKU: T12133
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12133Cas No. 2289691-01-4

Alias NUCC-0200975

MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.

MYCi975

🥰Excellent

Purity: 99.82%

Catalog No. T12133Alias NUCC-0200975Cas No. 2289691-01-4

MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.

Pack Size	Price	Availability
1 mg	$127	In Stock
5 mg	$297	In Stock
10 mg	$492	In Stock
25 mg	$819	In Stock
1 mL x 10 mM (in DMSO)	$383	In Stock

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

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COA LCMS

Product Introduction

Bioactivity

Description	MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.
In vitro	MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1].
In vivo	The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.
Synonyms	NUCC-0200975

Chemical Properties

Molecular Weight	561.3
Formula	C₂₅H₁₆Cl₂F₆N₂O₂
Cas No.	2289691-01-4
Smiles	O(CC1=CC=C(Cl)C=C1)C2=C(C(O)=C(C=C2)C3=CC(C(F)(F)F)=NN3C)C4=CC(C(F)(F)F)=C(Cl)C=C4
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247 mg/mL (440.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7816 mL	8.9079 mL	17.8158 mL	89.0789 mL
5 mM	0.3563 mL	1.7816 mL	3.5632 mL	17.8158 mL
10 mM	0.1782 mL	0.8908 mL	1.7816 mL	8.9079 mL
20 mM	0.0891 mL	0.4454 mL	0.8908 mL	4.4539 mL
50 mM	0.0356 mL	0.1782 mL	0.3563 mL	1.7816 mL
100 mM	0.0178 mL	0.0891 mL	0.1782 mL	0.8908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc