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CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.

  • CaMKP Inhibitor
    T215952789-62-5
    CaMKP Inhibitor can inhibit CaMKP.
    • $35
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  • Perphenazine
    T109058-39-9
    Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
    • $29
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  • Autocamtide 2 TFA(129198-88-5 free base)
    TP1217L
    Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMKII activity assay.
    • $87
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  • Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)
    TP1921L1
    Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide.
    • $133
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  • CALP2 acetate(261969-04-4 free base)
    TP1909L1
    CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently inhibits of adhesion and degranulation. CALP2 acetate is also a strong activator of alveolar macrophages. CALP2 acetate inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations.
    • $89
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  • CALP1 acetate
    TP1910L1
    CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
    • $133
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  • Syntide 2 acetate(108334-68-5 free base)
    TP1403L
    Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).
    • $81
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  • CaM kinase II inhibitor TFA salt
    TP1216
    CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
    • $177
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  • Calmodulin-Dependent Protein Kinase II 290-309 acetate
    TP1271L
    Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).
    • $221
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  • Nifedipine
    T114621829-25-4
    Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
    • $45
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  • Trifluoperazine
    T8389117-89-5
    Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
    • $41
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  • KN-62
    T2694127191-97-3
    KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
    • $30
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  • KN-93
    T2697139298-40-1
    KN-93 is a selective inhibitor of Ca2+ calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
    • $52
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  • Trifluoperazine dihydrochloride
    T1222440-17-5
    Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
    • $50
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  • STO-609
    T354652029-86-4
    STO-609 is a specific and cell-permeable inhibitor of the Ca2+ calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα KKβ (Ki: 80 15 ng mL).
    • $35
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  • Melatonin
    T165973-31-4
    Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
    • $31
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  • Psoralenoside
    TN1008905954-17-8
    Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
    • $122
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  • Rottlerin
    T1679182-08-6
    Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
    • $35
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  • A-484954
    TQ0137142557-61-7
    A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
    • $36
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  • KN-92 hydrochloride
    T85431431698-47-3
    KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM binding to the kinase with Ki of 370 nM.
    • $64
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  • KN-92 phosphate
    T45301135280-28-2
    KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+ calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
    • $47
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  • STO-609 acetate
    T36501173022-21-3
    STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the ATP-binding site. It displays > 80-fold selectivity over CaMK1/2/4, PKC, MLCK, PKA and p42 MAPK.
    • $40
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  • AC3-I, myristoylated
    T80269
    Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I). It acts as a highly specific inhibitor of Calmodulin-Dependent Protein Kinase II (CaMKII) with enhanced resistance to proteolysis. This compound is a derivative of Autocamtide-3, where the Thr-9 phosphorylation site is replaced by Ala.
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  • CaMKIIα-PHOTAC
    T79718
    CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule facilitates the ubiquitination and subsequent proteasome-mediated degradation of CaMKIIα when exposed to certain light wavelengths. Under illumination, CaMKIIα-PHOTAC diminishes synaptic functions and weakens evoked field excitatory postsynaptic potentials in the mouse hippocampus, thus impacting physiological responses. Additionally, it is crucial for sustaining long-term potentiation and memory functions within dendritic domains [1].
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  • A-7 hydrochloride
    T2253879127-24-5
    A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.
    • $35
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  • Phenoxybenzamine hydrochloride
    T115863-92-3
    Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
    • $42
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  • W-5 hydrochloride
    T2352361714-25-8
    W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.
    • $62
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  • Praeruptorin A
    T377773069-27-9
    Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis.
    • $59
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  • W-13 hydrochloride
    T2352288519-57-7
    W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.
    • $82
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  • W-7 hydrochloride
    T2079261714-27-0
    W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
    • $30
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  • KN-93 Phosphate
    T26061913269-12-1
    KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II with K i of 370 nM. KN-93 phosphate inhibits serum-induced fibroblast cell growth in a comparable dose-dependent fashion to its inhibition of CaMK-II activity.
    • $44
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  • Dibucaine
    T036485-79-0
    Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
    • $46
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  • Berbamine
    T3S0807478-61-5
    Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects.
    • $43
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  • Y-33075 dihydrochloride
    T13384L173897-44-4
    Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
    • $38
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  • A-3 hydrochloride
    T1406978957-85-4
    A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1]. A-3 hydrochloride against P
    • $30
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  • Autocamtide-2-related inhibitory peptide
    TP2310167114-91-2
    Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
    • $133
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  • NH125
    T6605278603-08-0
    NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
    • $34
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  • Calmodulin Kinase IINtide, Myristoylated
    T80549
    Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].
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  • Calmidazolium chloride
    T1066757265-65-3
    Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.
    • $57
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  • CaMKII-IN-1
    T148601208123-85-6
    CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.
    • $48
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  • Tanshinone IIA sulfonate sodium
    T294669659-80-9
    Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats.
    • $39
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  • Promethazine
    T044560-87-7
    Promethazine (Proazamine) is an analogue of anti-glaucoma prostaglandin (PG) .
    • $38
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  • Rimacalib
    T16752215174-50-8
    Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
    • $1,520
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  • W-9 hydrochloride
    T2352569762-85-2
    W-9 hydrochloride is a calmodulin antagonist.
    • $30
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  • lavendustin C
    T4185125697-93-0
    lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
    • $37
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  • Cloxacepride
    T6804865569-29-1
    cloxacepride is a CaM antagonist that is used to treat asthma disease.
    • $80
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  • Elziverine
    T6806495520-81-3
    Elziverine is an orally available small molecule calmodulin antagonist.Elziverine in vitro treatment inhibited Ca-loading-induced acanthocyte formation in SHRSP, WKY, and Wistar rats in a concentration-dependent manner.Elziverine can be used for the treatment of neurological disorders, and may be used for the study of cognitive disorders.
    • $280
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