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Sulfanilamide

Name: Sulfanilamide
Brand: TargetMol
SKU: T0123
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0123Cas No. 63-74-1

Alias UK-124, Sulphanilamide

Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

Sulfanilamide

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Purity: 99.76%

Catalog No. T0123Alias UK-124, SulphanilamideCas No. 63-74-1

Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
5 g	$53	-	In Stock
10 g	$74	-	In Stock
25 g	$118	-	In Stock
50 g	$175	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.76%

Appearance:Solid

Color:White to Brown

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COA LCMS HNMR

Product Introduction

Sulfanilamide AI Summary

Sulfanilamide exhibits bioactivity as an inhibitor of carbonic anhydrase (CA) enzymes, demonstrating significant inhibitory effects on various human CA isoforms. It shows inhibition constants (Ki) of 28,000.0 nM for CA I, 240.0 nM for CA II, 294.0 nM for CA IX, and 37.0 nM for CA XII. Additionally, it inhibits murine CA XIII with a Ki of 32.0 nM. Beyond its action on human CAs, Sulfanilamide also inhibits bacterial CAs from species such as Escherichia coli and Helicobacter pylori, with Ki values of 240.0 nM and 454.0 nM, respectively. The compound demonstrates potential therapeutic applications in areas where CA inhibition is beneficial, such as managing glaucoma, epilepsy, and certain bacterial infections. Furthermore, Sulfanilamide shows potent antibacterial activity against a range of bacteria including Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, as well as exhibiting antifungal activity against Candida albicans and Aspergillus niger. This broad-spectrum bioactivity suggests that Sulfanilamide may have versatile therapeutic potential in both antimicrobial and enzyme inhibition applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Targets&IC50	DHPS:320 μM
In vitro	Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM.
In vivo	Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM.
Synonyms	UK-124, Sulphanilamide

Chemical Properties

Molecular Weight	172.20
Formula	C₆H₈N₂O₂S
Cas No.	63-74-1
Smiles	Nc1ccc(cc1)S(N)(=O)=O
Relative Density.	1.08

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (290.36 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 14 mg/mL (81.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8072 mL	29.0360 mL	58.0720 mL	290.3600 mL
5 mM	1.1614 mL	5.8072 mL	11.6144 mL	58.0720 mL
10 mM	0.5807 mL	2.9036 mL	5.8072 mL	29.0360 mL
20 mM	0.2904 mL	1.4518 mL	2.9036 mL	14.5180 mL
50 mM	0.1161 mL	0.5807 mL	1.1614 mL	5.8072 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0581 mL	0.2904 mL	0.5807 mL	2.9036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc