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Ilaprazole

Name: Ilaprazole
Brand: TargetMol
SKU: T1756L
Rating: 4.5 (1 reviews)

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Catalog No. T1756LCas No. 172152-36-2

Alias IY-81149, IY81149, IY 81149

Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the development of reflux oesophagitis.

Ilaprazole

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Purity: 99.91%

Catalog No. T1756LAlias IY-81149, IY81149, IY 81149Cas No. 172152-36-2

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	Inquiry	Inquiry
5 mg	$64	Inquiry	Inquiry
10 mg	$98	Inquiry	Inquiry
25 mg	$197	Inquiry	Inquiry
50 mg	$328	Inquiry	Inquiry
100 mg	$497	Inquiry	Inquiry
500 mg	$1,080	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Ilaprazole AI Summary

Ilaprazole has antiviral activity against SARS-CoV-2, demonstrated by its ability to inhibit virus-induced cytotoxicity in VERO-6 cells. However, the compound exhibits a relatively high IC50 value of over 19952.62 nM, suggesting it may have weaker potency in inhibiting the virus at the concentrations tested..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the development of reflux oesophagitis.
Targets&IC50	H+, K+-ATPase:6.0 μM (IC50)
Synonyms	IY-81149, IY81149, IY 81149

Chemical Properties

Molecular Weight	366.44
Formula	C₁₉H₁₈N₄O₂S
Cas No.	172152-36-2
Smiles	S(CC1=C(C)C(OC)=CC=N1)(=O)C=2NC=3C(N2)=CC=C(C3)N4C=CC=C4
Relative Density.	1.39g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (163.74 mM), Sonication is recommended.

Ethanol: 12.5 mg/mL (34.11 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7290 mL	13.6448 mL	27.2896 mL	136.4480 mL
5 mM	0.5458 mL	2.7290 mL	5.4579 mL	27.2896 mL
10 mM	0.2729 mL	1.3645 mL	2.7290 mL	13.6448 mL
20 mM	0.1364 mL	0.6822 mL	1.3645 mL	6.8224 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0546 mL	0.2729 mL	0.5458 mL	2.7290 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc