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NEDD8 Protein, Human, Recombinant

Catalog No. TMPJ-01132
Synonyms: Ubiquitin-like protein Nedd8, NEDD8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8

Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
NEDD8 Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 13.00
50 μg 5 days $ 44.00
500 μg 5 days $ 200.00
1 mg 5 days $ 302.00
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Biological Description
Technical Params
Product Properties
Description Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.
Species Human
Expression System E. coli
Tag None
Accession Number Q15843
Synonyms Ubiquitin-like protein Nedd8, NEDD8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8
Amino Acid Met1-Gly76
Construction Recombinant Human Neural precursor cell expressed developmentally down-regulated protein 8 is produced by our E.coli expression system and the target gene encoding Met1-Gly76 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 9 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 250mM NaCl, pH 8.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.

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Keywords

NEDD8 Protein, Human, Recombinant NEDD 8 Ubiquitin-like protein Nedd8 NEDD-8 NEDD8 Neddylin Neural precursor cell expressed developmentally down-regulated protein 8 recombinant recombinant-proteins proteins protein

 

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