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RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) that specifically targets PLGF. It inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1, with IC50 values of 0.1 and 0.2 nM, respectively. RO5323441 effectively blocks PlGF-induced phosphorylation of VEGFR-1 in Flt-1 transfected HEK293 cells and exhibits antitumor activity.
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| 1 mg | Inquiry | Inquiry | Inquiry | |
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| Description | RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) that specifically targets PLGF. It inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1, with IC50 values of 0.1 and 0.2 nM, respectively. RO5323441 effectively blocks PlGF-induced phosphorylation of VEGFR-1 in Flt-1 transfected HEK293 cells and exhibits antitumor activity. |
| Synonyms | TB-403 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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