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JNJ-42165279

Name: JNJ-42165279
Brand: TargetMol
SKU: T3215
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3215Cas No. 1346528-50-4

Alias JNJ42165279

JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 μM) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG.

JNJ-42165279

🥰Excellent

Purity: 99.88%

Catalog No. T3215Alias JNJ42165279Cas No. 1346528-50-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$173	In Stock	In Stock
50 mg	$259	In Stock	In Stock
100 mg	$382	In Stock	In Stock
200 mg	$539	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$69	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 μM) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG.
Targets&IC50	FAAH (rat):313 ± 28 nM, FAAH (human):70 ± 8 nM
Synonyms	JNJ42165279

Chemical Properties

Molecular Weight	410.8
Formula	C₁₈H₁₇ClF₂N₄O₃
Cas No.	1346528-50-4
Smiles	FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)cc2O1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (109.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4343 mL	12.1714 mL	24.3427 mL	121.7137 mL
5 mM	0.4869 mL	2.4343 mL	4.8685 mL	24.3427 mL
10 mM	0.2434 mL	1.2171 mL	2.4343 mL	12.1714 mL
20 mM	0.1217 mL	0.6086 mL	1.2171 mL	6.0857 mL
50 mM	0.0487 mL	0.2434 mL	0.4869 mL	2.4343 mL
100 mM	0.0243 mL	0.1217 mL	0.2434 mL	1.2171 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc