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Anti-BLNK Antibody (2Y89)
😃Good
Catalog No. TMAB-03157
Anti-BLNK Antibody (2Y89) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2Y89) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P.
Anti-BLNK Antibody (2Y89)
Anti-BLNK Antibody (2Y89)
😃Good
Catalog No. TMAB-03157
Anti-BLNK Antibody (2Y89) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2Y89) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-BLNK Antibody (2Y89) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2Y89) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P. |
| Ig Type | IgG |
| Clone | 2Y89 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | FCM=1:50-100; ICC/IF=1:100-500; IF=1:50-200; IHC-Fr=1:50-200; IHC-P=1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction. |
| Tissue Specificity | Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. |
| Immunogen | A synthesized peptide: human BLNK |
| Antigen Species | Human |
| Gene Name | BLNK |
| Gene ID | |
| Protein Name | B-cell linker protein |
| Uniprot ID | |
| Function | Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Plays an important role in BCR-induced B-cell apoptosis. |
| Molecular Weight | Theoretical: 50 kDa. Actual: 70 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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